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Uterine, vaginal and placental blood flows increase with dynamic changes in serum metabolic parameters and oxidative stress across gestation in buffaloes

The aims of the present study were to determine uterine, vaginal and placental blood flows by Doppler ultrasound cross‐buffalo gestation and to evaluate the relationships among reproductive Doppler parameters and serum metabolic parameters as well as oxidative stress. Uterine (UA) and vaginal (VA) a...

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Published in:Reproduction in domestic animals 2021-01, Vol.56 (1), p.142-152
Main Authors: Elmetwally, Mohammed A., Elshopakey, Gehad E., Eldomany, Wael, Eldesouky, Ashraf, Samy, Alaa, Lenis, Yasser Y., Chen, Dong‐bao
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cited_by cdi_FETCH-LOGICAL-c3538-197dbd8a8c23763a37523ad3949e7bb1df3202928ac7070f5e91bd728c86f4653
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container_issue 1
container_start_page 142
container_title Reproduction in domestic animals
container_volume 56
creator Elmetwally, Mohammed A.
Elshopakey, Gehad E.
Eldomany, Wael
Eldesouky, Ashraf
Samy, Alaa
Lenis, Yasser Y.
Chen, Dong‐bao
description The aims of the present study were to determine uterine, vaginal and placental blood flows by Doppler ultrasound cross‐buffalo gestation and to evaluate the relationships among reproductive Doppler parameters and serum metabolic parameters as well as oxidative stress. Uterine (UA) and vaginal (VA) arteries were scanned every month, and placentome was scanned from month 4 till 8 in gestation. Time‐averaged maximum velocity (TAMV), pulsatility index (PI), resistance index (RI), systolic/diastolic ratio (SD) and arterial diameter (AD) were used for accessing UA and VA hemodynamics. Time‐averaged maximum velocity positively correlated with and AD, and both negatively correlated with their PI, RI and SD in UA and VA. TAMV and AD increased constantly in pregnancy, with maximum increase in months 4 and 9. Pulsatility index, RI and AD of UA decreased between months 4 and 9, while PI, RI and AD of VA decreased between months 5 and 9 and then increased in month 10 in pregnancy. Time‐averaged maximum velocity of placentome blood flow increased exponentially from months 4 to 8, but decreased at the last two months in pregnancy. Serum lipids were significantly higher in the first month compared to all other months, while glucose was significantly lower in months 9 and 10. Malondialdehyde increased from month 3 till term, but peaked in month 5 and 10. Glutathione and catalase were highest in the first month and remained after. Time‐averaged maximum velocity and AD for both UA and VA negatively correlated with serum lipids, glucose, catalase and glutathione, while positively correlated with malondialdehyde and total protein. Thus, increases in uterine blood flow (UtBF), vaginal blood flow (VaBF) and placental blood flow (PaBF) are associated with increased metabolism and oxidative stress in buffalo pregnancy.
doi_str_mv 10.1111/rda.13858
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Serum lipids were significantly higher in the first month compared to all other months, while glucose was significantly lower in months 9 and 10. Malondialdehyde increased from month 3 till term, but peaked in month 5 and 10. Glutathione and catalase were highest in the first month and remained after. Time‐averaged maximum velocity and AD for both UA and VA negatively correlated with serum lipids, glucose, catalase and glutathione, while positively correlated with malondialdehyde and total protein. 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Serum lipids were significantly higher in the first month compared to all other months, while glucose was significantly lower in months 9 and 10. Malondialdehyde increased from month 3 till term, but peaked in month 5 and 10. Glutathione and catalase were highest in the first month and remained after. Time‐averaged maximum velocity and AD for both UA and VA negatively correlated with serum lipids, glucose, catalase and glutathione, while positively correlated with malondialdehyde and total protein. Thus, increases in uterine blood flow (UtBF), vaginal blood flow (VaBF) and placental blood flow (PaBF) are associated with increased metabolism and oxidative stress in buffalo pregnancy.</description><subject>Arteries</subject><subject>Blood flow</subject><subject>Buffalo</subject><subject>buffaloes</subject><subject>Catalase</subject><subject>colour doppler</subject><subject>Correlation</subject><subject>Doppler effect</subject><subject>Gestation</subject><subject>Glucose</subject><subject>Glutathione</subject><subject>Hemodynamics</subject><subject>Lipids</subject><subject>Malondialdehyde</subject><subject>Metabolism</subject><subject>Oxidative metabolism</subject><subject>Oxidative stress</subject><subject>Parameters</subject><subject>Placenta</subject><subject>Pregnancy</subject><subject>Serum lipids</subject><subject>Ultrasound</subject><subject>uterine artery</subject><subject>Uterus</subject><subject>Vagina</subject><subject>Velocity</subject><issn>0936-6768</issn><issn>1439-0531</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp1kc1u1DAQgC1ERZfCgRdAlriARFr_JLZzrMpfpUpIiJ6jiT1pXSX2Yidd9lF4W7y7pYdK-DKemc-fbA8hbzg75WWdJQenXJrGPCMrXsu2Yo3kz8mKtVJVSitzTF7mfMcYb4zWL8ixlFzXQvIV-XM9Y_IBP9J7uPEBRgrB0fUIFsNcsn6M0dFhjJtMfbAJISPd-PmWum2AyVtqbyHc4K5LM6ZlohPO0MextNaQoGSY8t4af3sHs79HmueEuRRtiiWU03Opx7Bz9MswwBgxvyJHZZPx9UM8IddfPv-8-FZdff96eXF-VVnZSFPxVrveGTBWSK0kSN0ICU62dYu677kbpGCiFQasZpoNDba8d1oYa9RQq0aekPcH7zrFX0u5Sjf5bHEcIWBccifqplXF3dQFffcEvYtLKp-2o7RRRkmhC_XhQO1fl3Do1slPkLYdZ91uXl2ZV7efV2HfPhiXfkL3SP4bUAHODsDGj7j9v6n78en8oPwLhpWhKA</recordid><startdate>202101</startdate><enddate>202101</enddate><creator>Elmetwally, Mohammed A.</creator><creator>Elshopakey, Gehad E.</creator><creator>Eldomany, Wael</creator><creator>Eldesouky, Ashraf</creator><creator>Samy, Alaa</creator><creator>Lenis, Yasser Y.</creator><creator>Chen, Dong‐bao</creator><general>Blackwell Publishing Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7486-7756</orcidid></search><sort><creationdate>202101</creationdate><title>Uterine, vaginal and placental blood flows increase with dynamic changes in serum metabolic parameters and oxidative stress across gestation in buffaloes</title><author>Elmetwally, Mohammed A. ; 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Uterine (UA) and vaginal (VA) arteries were scanned every month, and placentome was scanned from month 4 till 8 in gestation. Time‐averaged maximum velocity (TAMV), pulsatility index (PI), resistance index (RI), systolic/diastolic ratio (SD) and arterial diameter (AD) were used for accessing UA and VA hemodynamics. Time‐averaged maximum velocity positively correlated with and AD, and both negatively correlated with their PI, RI and SD in UA and VA. TAMV and AD increased constantly in pregnancy, with maximum increase in months 4 and 9. Pulsatility index, RI and AD of UA decreased between months 4 and 9, while PI, RI and AD of VA decreased between months 5 and 9 and then increased in month 10 in pregnancy. Time‐averaged maximum velocity of placentome blood flow increased exponentially from months 4 to 8, but decreased at the last two months in pregnancy. Serum lipids were significantly higher in the first month compared to all other months, while glucose was significantly lower in months 9 and 10. Malondialdehyde increased from month 3 till term, but peaked in month 5 and 10. Glutathione and catalase were highest in the first month and remained after. Time‐averaged maximum velocity and AD for both UA and VA negatively correlated with serum lipids, glucose, catalase and glutathione, while positively correlated with malondialdehyde and total protein. Thus, increases in uterine blood flow (UtBF), vaginal blood flow (VaBF) and placental blood flow (PaBF) are associated with increased metabolism and oxidative stress in buffalo pregnancy.</abstract><cop>Germany</cop><pub>Blackwell Publishing Ltd</pub><pmid>33174231</pmid><doi>10.1111/rda.13858</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0001-7486-7756</orcidid></addata></record>
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subjects Arteries
Blood flow
Buffalo
buffaloes
Catalase
colour doppler
Correlation
Doppler effect
Gestation
Glucose
Glutathione
Hemodynamics
Lipids
Malondialdehyde
Metabolism
Oxidative metabolism
Oxidative stress
Parameters
Placenta
Pregnancy
Serum lipids
Ultrasound
uterine artery
Uterus
Vagina
Velocity
title Uterine, vaginal and placental blood flows increase with dynamic changes in serum metabolic parameters and oxidative stress across gestation in buffaloes
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