Radiomics and radiogenomics in ovarian cancer: a literature review

Ovarian cancer remains one of the most lethal gynecological cancers in the world despite extensive progress in the areas of chemotherapy and surgery. Many studies have postulated that this is because of the profound heterogeneity that underpins response to therapy and prognosis. Standard imaging eva...

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Bibliographic Details
Published in:Abdominal imaging 2021-06, Vol.46 (6), p.2308-2322
Main Authors: Nougaret, S., McCague, Cathal, Tibermacine, Hichem, Vargas, Hebert Alberto, Rizzo, Stefania, Sala, E.
Format: Article
Language:English
Subjects:
Biopsy
Cancer
Carcinoma, Ovarian Epithelial
Chemotherapy
Computed tomography
Evaluation
Female
Gastric cancer
Gastroenterology
Genomics
Hepatology
Heterogeneity
Humans
Imaging
Literature reviews
Magnetic Resonance Imaging
Medicine
Medicine & Public Health
Ovarian cancer
Ovarian Neoplasms - diagnostic imaging
Ovarian Neoplasms - genetics
Peritoneal Neoplasms
Peritoneum
Prognosis
Proteomics
Radiation therapy
Radiology
Radiomics
Special Section: Ovarian Cancer
Surgery
Targeted cancer therapy
Tumors
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Summary:Ovarian cancer remains one of the most lethal gynecological cancers in the world despite extensive progress in the areas of chemotherapy and surgery. Many studies have postulated that this is because of the profound heterogeneity that underpins response to therapy and prognosis. Standard imaging evaluation using CT or MRI does not take into account this tumoral heterogeneity especially in advanced stages with peritoneal carcinomatosis. As such, newly emergent fields in the assessment of tumor heterogeneity have been proposed using radiomics to evaluate the whole tumor burden heterogeneity as opposed to single biopsy sampling. This review provides an overview of radiomics, radiogenomics, and proteomics and examines the use of these newly emergent fields in assessing tumor heterogeneity and its implications in ovarian cancer.
ISSN:2366-004X
2366-0058
DOI:10.1007/s00261-020-02820-z