Laparoscopic adenomyomectomy combined with levonorgestrel‐releasing intrauterine system in the treatment of adenomyosis: Feasibility and effectiveness

Aim To evaluate the clinical efficacy and safety of laparoscopic adenomyomectomy combined with intraoperative replacement of levonorgestrel‐releasing intrauterine system (LNG‐IUS) in the treatment of symptomatic adenomyosis. Methods This is a case‐series study in a university medical center. A total...

Full description

Saved in:
Bibliographic Details
Published in:The journal of obstetrics and gynaecology research 2021-02, Vol.47 (2), p.613-620
Main Authors: Sun, Feng, Zhang, Ye, You, Min, Yang, YePing, Yu, YingYing, Xu, Hong
Format: Article
Language:English
Subjects:
adenomyosis
Amenorrhea
conservative surgery
laparoscopic adenomyomectomy
Laparoscopy
levonorgestrel‐releasing intrauterine system
Menstruation
Patients
Side effects
Surgery
Uterus
Vagina
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites
container_end_page 620
container_issue 2
container_start_page 613
container_title The journal of obstetrics and gynaecology research
container_volume 47
creator Sun, Feng
Zhang, Ye
You, Min
Yang, YePing
Yu, YingYing
Xu, Hong
description Aim To evaluate the clinical efficacy and safety of laparoscopic adenomyomectomy combined with intraoperative replacement of levonorgestrel‐releasing intrauterine system (LNG‐IUS) in the treatment of symptomatic adenomyosis. Methods This is a case‐series study in a university medical center. A total of 52 patients with symptomatic adenomyosis were treated by laparoscopic adenomyomectomy combined with intraoperative replacement of LNG‐IUS from January 2015 to July 2018. Visual analog scale, menstrual flow and uterine volume were compared before and after the surgery (3, 12 and 24 months). Meanwhile, LNG‐IUS‐induced adverse reactions (e.g. irregular vaginal bleeding, amenorrhea, expulsion, and perforation) were also recorded. Results All operations were successfully completed via laparoscopy without conversion to laparotomy. No severe complications were noted during the surgical procedure or follow‐up period. The mean postoperative visual analog scale and menstrual flow scores and the volume of the uterus were significantly decreased (all P 
doi_str_mv 10.1111/jog.14571
format article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_2459623835</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2459623835</sourcerecordid><originalsourceid>FETCH-LOGICAL-j3031-cb50f3fcd0a6ba4dad88ae9a4dcaeefe837fc2534faa5b4b0fe7d2214c4b6aa23</originalsourceid><addsrcrecordid>eNpdkc1O3DAQx6OqFVDKoS9QWeqll4Ad27G3twoVWrQSl_YcTZzx4lVib20HlBuP0GOfjyfBfJQDc_D85fnNhz1V9ZHRY1bsZBs2x0xIxd5UB0wIVVMl27dFc8FqTVW7X71PaUspUyum96p9zpkSnOmD6t8adhBDMmHnDIEBfZiWMKHJxRMTpt55HMiNy1dkxOvgQ9xgyhHHu9u_5URIzm-I8znCnDEWmqQlZZzKHclXSAoLeUKfSbAvDZJLX8nZQ3LvRpcXAn4gaG3p667RY0ofqncWxoRHz_6w-n32_dfpj3p9ef7z9Nu63nLKWW16SS23ZqDQ9iAGGLQGXBVlANGi5sqaRnJhAWQvempRDU3DhBF9C9Dww-rLU91dDH_m8rRucsngOILHMKeuEXLVNlxzWdDPr9BtmKMv0xVKU6mkbnmhPj1Tcz_h0O2imyAu3f8_L8DJE3DjRlxe4ox2D8ssNTfd4zK7i8vzR8HvAR94mHM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2480575863</pqid></control><display><type>article</type><title>Laparoscopic adenomyomectomy combined with levonorgestrel‐releasing intrauterine system in the treatment of adenomyosis: Feasibility and effectiveness</title><source>Wiley</source><creator>Sun, Feng ; Zhang, Ye ; You, Min ; Yang, YePing ; Yu, YingYing ; Xu, Hong</creator><creatorcontrib>Sun, Feng ; Zhang, Ye ; You, Min ; Yang, YePing ; Yu, YingYing ; Xu, Hong</creatorcontrib><description>Aim To evaluate the clinical efficacy and safety of laparoscopic adenomyomectomy combined with intraoperative replacement of levonorgestrel‐releasing intrauterine system (LNG‐IUS) in the treatment of symptomatic adenomyosis. Methods This is a case‐series study in a university medical center. A total of 52 patients with symptomatic adenomyosis were treated by laparoscopic adenomyomectomy combined with intraoperative replacement of LNG‐IUS from January 2015 to July 2018. Visual analog scale, menstrual flow and uterine volume were compared before and after the surgery (3, 12 and 24 months). Meanwhile, LNG‐IUS‐induced adverse reactions (e.g. irregular vaginal bleeding, amenorrhea, expulsion, and perforation) were also recorded. Results All operations were successfully completed via laparoscopy without conversion to laparotomy. No severe complications were noted during the surgical procedure or follow‐up period. The mean postoperative visual analog scale and menstrual flow scores and the volume of the uterus were significantly decreased (all P &lt; 0.001) at 3, 12, and 24 months postoperatively, compared with preoperative scores. The clinical effective rates among the patients with dysmenorrhea were 98%, 96% and 96% at 3, 12 and 24 months after the operation, respectively. And the clinical effectiveness rate of menorrhagia was 97.6%, 95.2% and 95.2% at 3, 12 and 24 months after treatment, respectively. Among all related adverse reactions, amenorrhea was the most common (n = 12, 23.1%). There was one case of LNG‐IUS perforation (1.9%) and two cases of expulsion (3.8%). Conclusion Laparoscopic adenomyomectomy combined with intraoperative replacement of LNG‐IUS is a novel and effective conservative surgical procedure for symptomatic adenomyosis treatment.</description><identifier>ISSN: 1341-8076</identifier><identifier>EISSN: 1447-0756</identifier><identifier>DOI: 10.1111/jog.14571</identifier><identifier>PMID: 33174318</identifier><language>eng</language><publisher>Kyoto, Japan: John Wiley &amp; Sons Australia, Ltd</publisher><subject>adenomyosis ; Amenorrhea ; conservative surgery ; laparoscopic adenomyomectomy ; Laparoscopy ; levonorgestrel‐releasing intrauterine system ; Menstruation ; Patients ; Side effects ; Surgery ; Uterus ; Vagina</subject><ispartof>The journal of obstetrics and gynaecology research, 2021-02, Vol.47 (2), p.613-620</ispartof><rights>2020 Japan Society of Obstetrics and Gynecology</rights><rights>2020 Japan Society of Obstetrics and Gynecology.</rights><rights>2021 Japan Society of Obstetrics and Gynecology</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33174318$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sun, Feng</creatorcontrib><creatorcontrib>Zhang, Ye</creatorcontrib><creatorcontrib>You, Min</creatorcontrib><creatorcontrib>Yang, YePing</creatorcontrib><creatorcontrib>Yu, YingYing</creatorcontrib><creatorcontrib>Xu, Hong</creatorcontrib><title>Laparoscopic adenomyomectomy combined with levonorgestrel‐releasing intrauterine system in the treatment of adenomyosis: Feasibility and effectiveness</title><title>The journal of obstetrics and gynaecology research</title><addtitle>J Obstet Gynaecol Res</addtitle><description>Aim To evaluate the clinical efficacy and safety of laparoscopic adenomyomectomy combined with intraoperative replacement of levonorgestrel‐releasing intrauterine system (LNG‐IUS) in the treatment of symptomatic adenomyosis. Methods This is a case‐series study in a university medical center. A total of 52 patients with symptomatic adenomyosis were treated by laparoscopic adenomyomectomy combined with intraoperative replacement of LNG‐IUS from January 2015 to July 2018. Visual analog scale, menstrual flow and uterine volume were compared before and after the surgery (3, 12 and 24 months). Meanwhile, LNG‐IUS‐induced adverse reactions (e.g. irregular vaginal bleeding, amenorrhea, expulsion, and perforation) were also recorded. Results All operations were successfully completed via laparoscopy without conversion to laparotomy. No severe complications were noted during the surgical procedure or follow‐up period. The mean postoperative visual analog scale and menstrual flow scores and the volume of the uterus were significantly decreased (all P &lt; 0.001) at 3, 12, and 24 months postoperatively, compared with preoperative scores. The clinical effective rates among the patients with dysmenorrhea were 98%, 96% and 96% at 3, 12 and 24 months after the operation, respectively. And the clinical effectiveness rate of menorrhagia was 97.6%, 95.2% and 95.2% at 3, 12 and 24 months after treatment, respectively. Among all related adverse reactions, amenorrhea was the most common (n = 12, 23.1%). There was one case of LNG‐IUS perforation (1.9%) and two cases of expulsion (3.8%). Conclusion Laparoscopic adenomyomectomy combined with intraoperative replacement of LNG‐IUS is a novel and effective conservative surgical procedure for symptomatic adenomyosis treatment.</description><subject>adenomyosis</subject><subject>Amenorrhea</subject><subject>conservative surgery</subject><subject>laparoscopic adenomyomectomy</subject><subject>Laparoscopy</subject><subject>levonorgestrel‐releasing intrauterine system</subject><subject>Menstruation</subject><subject>Patients</subject><subject>Side effects</subject><subject>Surgery</subject><subject>Uterus</subject><subject>Vagina</subject><issn>1341-8076</issn><issn>1447-0756</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNpdkc1O3DAQx6OqFVDKoS9QWeqll4Ad27G3twoVWrQSl_YcTZzx4lVib20HlBuP0GOfjyfBfJQDc_D85fnNhz1V9ZHRY1bsZBs2x0xIxd5UB0wIVVMl27dFc8FqTVW7X71PaUspUyum96p9zpkSnOmD6t8adhBDMmHnDIEBfZiWMKHJxRMTpt55HMiNy1dkxOvgQ9xgyhHHu9u_5URIzm-I8znCnDEWmqQlZZzKHclXSAoLeUKfSbAvDZJLX8nZQ3LvRpcXAn4gaG3p667RY0ofqncWxoRHz_6w-n32_dfpj3p9ef7z9Nu63nLKWW16SS23ZqDQ9iAGGLQGXBVlANGi5sqaRnJhAWQvempRDU3DhBF9C9Dww-rLU91dDH_m8rRucsngOILHMKeuEXLVNlxzWdDPr9BtmKMv0xVKU6mkbnmhPj1Tcz_h0O2imyAu3f8_L8DJE3DjRlxe4ox2D8ssNTfd4zK7i8vzR8HvAR94mHM</recordid><startdate>202102</startdate><enddate>202102</enddate><creator>Sun, Feng</creator><creator>Zhang, Ye</creator><creator>You, Min</creator><creator>Yang, YePing</creator><creator>Yu, YingYing</creator><creator>Xu, Hong</creator><general>John Wiley &amp; Sons Australia, Ltd</general><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>7T5</scope><scope>7TO</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>202102</creationdate><title>Laparoscopic adenomyomectomy combined with levonorgestrel‐releasing intrauterine system in the treatment of adenomyosis: Feasibility and effectiveness</title><author>Sun, Feng ; Zhang, Ye ; You, Min ; Yang, YePing ; Yu, YingYing ; Xu, Hong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j3031-cb50f3fcd0a6ba4dad88ae9a4dcaeefe837fc2534faa5b4b0fe7d2214c4b6aa23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>adenomyosis</topic><topic>Amenorrhea</topic><topic>conservative surgery</topic><topic>laparoscopic adenomyomectomy</topic><topic>Laparoscopy</topic><topic>levonorgestrel‐releasing intrauterine system</topic><topic>Menstruation</topic><topic>Patients</topic><topic>Side effects</topic><topic>Surgery</topic><topic>Uterus</topic><topic>Vagina</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sun, Feng</creatorcontrib><creatorcontrib>Zhang, Ye</creatorcontrib><creatorcontrib>You, Min</creatorcontrib><creatorcontrib>Yang, YePing</creatorcontrib><creatorcontrib>Yu, YingYing</creatorcontrib><creatorcontrib>Xu, Hong</creatorcontrib><collection>PubMed</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of obstetrics and gynaecology research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sun, Feng</au><au>Zhang, Ye</au><au>You, Min</au><au>Yang, YePing</au><au>Yu, YingYing</au><au>Xu, Hong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Laparoscopic adenomyomectomy combined with levonorgestrel‐releasing intrauterine system in the treatment of adenomyosis: Feasibility and effectiveness</atitle><jtitle>The journal of obstetrics and gynaecology research</jtitle><addtitle>J Obstet Gynaecol Res</addtitle><date>2021-02</date><risdate>2021</risdate><volume>47</volume><issue>2</issue><spage>613</spage><epage>620</epage><pages>613-620</pages><issn>1341-8076</issn><eissn>1447-0756</eissn><abstract>Aim To evaluate the clinical efficacy and safety of laparoscopic adenomyomectomy combined with intraoperative replacement of levonorgestrel‐releasing intrauterine system (LNG‐IUS) in the treatment of symptomatic adenomyosis. Methods This is a case‐series study in a university medical center. A total of 52 patients with symptomatic adenomyosis were treated by laparoscopic adenomyomectomy combined with intraoperative replacement of LNG‐IUS from January 2015 to July 2018. Visual analog scale, menstrual flow and uterine volume were compared before and after the surgery (3, 12 and 24 months). Meanwhile, LNG‐IUS‐induced adverse reactions (e.g. irregular vaginal bleeding, amenorrhea, expulsion, and perforation) were also recorded. Results All operations were successfully completed via laparoscopy without conversion to laparotomy. No severe complications were noted during the surgical procedure or follow‐up period. The mean postoperative visual analog scale and menstrual flow scores and the volume of the uterus were significantly decreased (all P &lt; 0.001) at 3, 12, and 24 months postoperatively, compared with preoperative scores. The clinical effective rates among the patients with dysmenorrhea were 98%, 96% and 96% at 3, 12 and 24 months after the operation, respectively. And the clinical effectiveness rate of menorrhagia was 97.6%, 95.2% and 95.2% at 3, 12 and 24 months after treatment, respectively. Among all related adverse reactions, amenorrhea was the most common (n = 12, 23.1%). There was one case of LNG‐IUS perforation (1.9%) and two cases of expulsion (3.8%). Conclusion Laparoscopic adenomyomectomy combined with intraoperative replacement of LNG‐IUS is a novel and effective conservative surgical procedure for symptomatic adenomyosis treatment.</abstract><cop>Kyoto, Japan</cop><pub>John Wiley &amp; Sons Australia, Ltd</pub><pmid>33174318</pmid><doi>10.1111/jog.14571</doi><tpages>8</tpages></addata></record>
fulltext fulltext
identifier ISSN: 1341-8076
ispartof The journal of obstetrics and gynaecology research, 2021-02, Vol.47 (2), p.613-620
issn 1341-8076
1447-0756
language eng
recordid cdi_proquest_miscellaneous_2459623835
source Wiley
subjects adenomyosis
Amenorrhea
conservative surgery
laparoscopic adenomyomectomy
Laparoscopy
levonorgestrel‐releasing intrauterine system
Menstruation
Patients
Side effects
Surgery
Uterus
Vagina
title Laparoscopic adenomyomectomy combined with levonorgestrel‐releasing intrauterine system in the treatment of adenomyosis: Feasibility and effectiveness
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T19%3A20%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Laparoscopic%20adenomyomectomy%20combined%20with%20levonorgestrel%E2%80%90releasing%20intrauterine%20system%20in%20the%20treatment%20of%20adenomyosis:%20Feasibility%20and%20effectiveness&rft.jtitle=The%20journal%20of%20obstetrics%20and%20gynaecology%20research&rft.au=Sun,%20Feng&rft.date=2021-02&rft.volume=47&rft.issue=2&rft.spage=613&rft.epage=620&rft.pages=613-620&rft.issn=1341-8076&rft.eissn=1447-0756&rft_id=info:doi/10.1111/jog.14571&rft_dat=%3Cproquest_pubme%3E2459623835%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-j3031-cb50f3fcd0a6ba4dad88ae9a4dcaeefe837fc2534faa5b4b0fe7d2214c4b6aa23%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2480575863&rft_id=info:pmid/33174318&rfr_iscdi=true