Does Ibuprofen Increase Bleed Risk for Pediatric Tonsillectomy?

Objective To evaluate risk factors for pediatric posttonsillectomy hemorrhage (PTH) and the need for transfusion using a national database. Study Design Retrospective cohort study. Setting The study was conducted using the Pediatric Health Information System (PHIS) database. Methods Children ≤18 yea...

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Bibliographic Details
Published in:Otolaryngology-head and neck surgery 2021-07, Vol.165 (1), p.187-196
Main Authors: Leung, Peggy, DeVore, Elliana Kirsh, Kawai, Kosuke, Yuen, Sonia, Kenna, Margaret, Irace, Alexandria L., Roberson, David, Adil, Eelam
Format: Article
Language:English
Subjects:
adenoidectomy
bleeding
hemorrhage
ibuprofen
ketorolac
NSAIDs
obstructive sleep apnea
pediatric
tonsil bleed
tonsillectomy
tonsillitis
transfusion
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Summary:Objective To evaluate risk factors for pediatric posttonsillectomy hemorrhage (PTH) and the need for transfusion using a national database. Study Design Retrospective cohort study. Setting The study was conducted using the Pediatric Health Information System (PHIS) database. Methods Children ≤18 years who underwent tonsillectomy with or without adenoidectomy (T±A) between 2004 and 2015 were included. We evaluated the risk of PTH requiring cauterization according to patient demographics, comorbidities, indication for surgery, medications, year of surgery, and geographic region. Results Of the 551,137 PHIS patients who underwent T±A, 8735 patients (1.58%) experienced a PTH. The risk of PTH increased from 1.33% (95% confidence interval [CI]: 1.15%, 1.53%) in 2010 to 1.91% (95% CI: 1.64%, 2.24%) in 2015 (P < .001). Older age (≥12 vs
ISSN:0194-5998
1097-6817
DOI:10.1177/0194599820970943