Protective effect of Corynoline on the CFA induced Rheumatoid arthritis via attenuation of oxidative and inflammatory mediators

Rheumatoid arthritis (RA) is a long-standing and growing autoimmune disease. Therefore, the present study was intended to investigate the effect of Corynoline (COR) on CFA induced rheumatoid arthritis in a rat model. Results suggested that COR causes significant reduction in paw swelling, edema, art...

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Bibliographic Details
Published in:Molecular and cellular biochemistry 2021-02, Vol.476 (2), p.831-839
Main Authors: Weng, Weifeng, Wang, Fuyong, He, Xiaojian, Zhou, Kaihua, Wu, Xiaotian, Wu, Xiao
Format: Article
Language:English
Subjects:
Analysis
Antioxidants
Antirheumatic agents
Arthritis
Attenuation
Autoimmune diseases
Biochemistry
Biomedical and Life Sciences
Cardiology
Cartilage
Collagen (type II)
Cyclooxygenase-2
Cytokines
Edema
Enzymes
Immunoglobulin G
Immunoglobulins
Inflammation
Interleukins
Leukocytes (neutrophilic)
Life Sciences
Liquid oxygen
Medical Biochemistry
Medical research
Medicine, Experimental
Oncology
Oxidative stress
Reduction
Rheumatoid arthritis
Rheumatoid factor
Spleen
Tofacitinib
Tumor necrosis factor
Tumor necrosis factor-α
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Summary:Rheumatoid arthritis (RA) is a long-standing and growing autoimmune disease. Therefore, the present study was intended to investigate the effect of Corynoline (COR) on CFA induced rheumatoid arthritis in a rat model. Results suggested that COR causes significant reduction in paw swelling, edema, arthritis score, thymus and spleen indexes and neutrophil infiltration ( p  
ISSN:0300-8177
1573-4919
DOI:10.1007/s11010-020-03948-8