Association of non-thyroidal illness syndrome with interleukin-6 and interleukin-10 in critically ill children with sepsis

To study the incidence rate of non-thyroidal illness syndrome (NTIS) in critically ill children with or without sepsis and the association of NTIS with interleukin-6 (IL-6) and interleukin-10 (IL-10). A retrospective analysis was performed on the medical data of 97 children with sepsis (sepsis group...

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Published in:Zhongguo dang dai er ke za zhi 2020-11, Vol.22 (11), p.1215-1220
Main Authors: Xu, Mei-Xian, Liu, Gang, Cao, Li-Jing, Bai, Xin-Feng, Kang, Lei, Zhao, Xin, Shi, Xiao-Na, Li, Li-Jing
Format: Article
Language:Chinese
Subjects:
Child
Critical Illness
Euthyroid Sick Syndromes
Humans
Interleukin-10 - blood
Interleukin-6 - blood
Retrospective Studies
Sepsis
Thyrotropin
Thyroxine
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Summary:To study the incidence rate of non-thyroidal illness syndrome (NTIS) in critically ill children with or without sepsis and the association of NTIS with interleukin-6 (IL-6) and interleukin-10 (IL-10). A retrospective analysis was performed on the medical data of 97 children with sepsis (sepsis group) and 80 non-sepsis children with bacterial infection (non-sepsis group). The correlations of IL-6 and IL-10 with the thyroid function parameters triiodothyronine (T3), thyroxine (T4), and thyroid stimulating hormone (TSH) were analyzed. There were no significant differences in age and sex between the sepsis and non-sepsis groups (P>0.05). Compared with the non-sepsis group, the sepsis group had a significantly higher Sequential Organ Failure Assessment score, a significantly longer length of hospital stay, and a significantly higher rate of use of ventilator (P
ISSN:1008-8830