Alterations in peripheral blood monocyte and dendritic cell subset homeostasis in relapsing-remitting multiple sclerosis patients

• Published in: Journal of neuroimmunology 2021-01, Vol.350, p.577433-577433, Article 577433
• Main Authors: Monteiro, Andreia, Rosado, Pedro, Rosado, Luiza, Fonseca, Ana Mafalda, Coucelo, Margarida, Paiva, Artur
• Format: Article
• Language: English
• Subjects: Dendritic cells; IFN-β therapy; Monocytes; Multiple sclerosis
• ISSN: 0165-5728; 1872-8421
• DOI: 10.1016/j.jneuroim.2020.577433

Antigen-presenting cells participate and are implicated in the pathogenesis of multiple sclerosis. In our study we assessed the frequency of plasmacytoid (pDC) and myeloid (mDC) dendritic cells and the classical, intermediate and non-classical monocytes subsets, as well as their phenotypic and functional profile. We evaluated peripheral blood from relapsing-remitting patients treated with IFN-β in remission and relapse phases and from healthy subjects. In remission, we observed a decrease of mDC/pDC ratio and a return to normal values in relapse. In both phases the frequency of non-classical monocytes decreases. Concerning the phenotypic characterization, an increased HLA-DR expression was observed in remission and a decrease in relapse, revealing alterations in monocytes and dendritic cells homeostasis. •The mDC/pDC ratio decreases in remission and increases in relapse of RRMS patients.•Frequency of non-classical monocytes decreased in RRMS patients.•Increased HLA-DR expression in DC and monocyte subsets in remission patients.