Chemical features of blood-borne TRG CDR3s associated with an increased overall survival in breast cancer

Purpose Immunogenomics and earlier, pioneering studies, particularly by Whiteside and colleagues, have indicated a positive role for B-cells in breast cancer, as well as a positive role for gamma-delta T-cells. However, these studies have been completely limited to assessing breast cancer tumor tiss...

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Bibliographic Details
Published in:Breast cancer research and treatment 2021-02, Vol.185 (3), p.591-600
Main Authors: Chobrutskiy, Andrea, Chobrutskiy, Boris I., Zaman, Saif, Hsiang, Monica, Blanck, George
Format: Article
Language:English
Subjects:
Amino acid sequence
Blood cancer
Breast cancer
Cancer patients
Cancer research
Comparative analysis
Complementarity-determining region 3
Development and progression
Estrogen
Lymphocytes B
Lymphocytes T
Medicine
Medicine & Public Health
Oncology
Patient outcomes
Preclinical Study
Progesterone
T cell receptors
T cells
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Summary:Purpose Immunogenomics and earlier, pioneering studies, particularly by Whiteside and colleagues, have indicated a positive role for B-cells in breast cancer, as well as a positive role for gamma-delta T-cells. However, these studies have been completely limited to assessing breast cancer tumor tissue. Methods and Results Our analyses here has shown that blood-borne T-cell receptor gamma (TRG) chain sequences were associated with greater overall survival, of particular note due to the comparative longevity of primary breast cancer patients, whereby assessments of disease-free, but rarely overall survival parameters are possible. Additional immunogenomics approaches narrowed the overall survival correlations to specific, TRG complementarity determining region-3, amino acid (AA) sequence chemical features, independently of many common, confounding variables in the breast cancer setting, such as estrogen or progesterone receptor status. Conclusions These results are discussed in the context of patient age and with regard to potential antigenic targets, based on the chemistry of the TRG CDR3 AA sequences associated with the higher survival rates.
ISSN:0167-6806
1573-7217
DOI:10.1007/s10549-020-05996-6