Imaging fibroblast activation protein in liver cancer: a single-center post hoc retrospective analysis to compare [68Ga]Ga-FAPI-04 PET/CT versus MRI and [18F]-FDG PET/CT

Purpose This study aimed to evaluate the potential utility of [ 68 Ga]Ga-FAPI-04 PET/CT for diagnosing primary and metastatic lesions in patients with liver cancer, as well as to compare it with contrast-enhanced CT (CE-CT), liver MRI, and [ 18 F]-FDG PET/CT. Methods We performed a single-center pos...

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Bibliographic Details
Published in:European journal of nuclear medicine and molecular imaging 2021-05, Vol.48 (5), p.1604-1617
Main Authors: Guo, Wei, Pang, Yizhen, Yao, Lanlin, Zhao, Liang, Fan, Chunlei, Ke, Jingpeng, Guo, Ping, Hao, Bing, Fu, Hao, Xie, Chengrong, Lin, Qin, Wu, Hua, Sun, Long, Chen, Haojun
Format: Article
Language:English
Subjects:
Cardiology
Computed tomography
Diagnosis
Fibroblast activation protein
Fluorine isotopes
Hepatocellular carcinoma
Imaging
Lesions
Liver cancer
Magnetic resonance imaging
Medicine
Medicine & Public Health
Metastases
Metastasis
Nodules
Nuclear Medicine
Oncology
Oncology – Digestive tract
Original Article
Orthopedics
Positron emission
Positron emission tomography
Radiology
Sensitivity
Tomography
Tumors
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Summary:Purpose This study aimed to evaluate the potential utility of [ 68 Ga]Ga-FAPI-04 PET/CT for diagnosing primary and metastatic lesions in patients with liver cancer, as well as to compare it with contrast-enhanced CT (CE-CT), liver MRI, and [ 18 F]-FDG PET/CT. Methods We performed a single-center post hoc retrospective analysis of data obtained from a prospective parent study (NCT04416165). This study included 34 patients diagnosed with or suspected hepatic lesions who underwent concomitant [ 68 Ga]Ga-FAPI-04 and [ 18 F]-FDG/CT scans. Moreover, these patients underwent liver MRI ( n  = 34) and CE-CT ( n  = 25). Histopathologic ( n  = 62) or radiographic follow-up ( n  = 128) served as the reference standard for the final diagnosis. Results Among the 34 patients, 20, 12, and 2 patients presented with hepatocellular carcinomas, intrahepatic cholangiocarcinomas, and benign hepatic nodules, respectively. The sensitivities of CE-CT, MRI, [ 68 Ga]Ga-FAPI-04, and [ 18 F]-FDG/CT for detecting primary liver tumors were 96%, 100%, 96%, and 65%, respectively. Regarding the diagnosis of all intrahepatic lesions, the per-lesion detection rate of [ 68 Ga]Ga-FAPI-04 PET/CT was slightly lower than that of MRI (85% vs. 100%, P  = 0.34) and significantly higher than that of [ 18 F]-FDG PET/CT (85% vs. 52%, P  
ISSN:1619-7070
1619-7089
DOI:10.1007/s00259-020-05095-0