Systemic immune-inflammation index is a novel marker to predict functionally significant coronary artery stenosis

The study aimed to investigate and compare the predictive capacity of a systemic immune-inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) to determine a hemodynamically significant coronary artery stenosis assessed by fractional flow reserve (FFR)....

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Bibliographic Details
Published in:Biomarkers in medicine 2020-11, Vol.14 (16), p.1553-1561
Main Authors: Erdoğan, Mehmet, Erdöl, Mehmet A, Öztürk, Selçuk, Durmaz, Tahir
Format: Article
Language:English
Subjects:
Acute coronary syndromes
Adenosine
Biomarkers
Blood platelets
Blood tests
Cardiology
Cardiovascular disease
coronary angiography
Coronary artery
Coronary vessels
Creatinine
fractional flow reserve
Glucose
Heart surgery
Hypertension
Inflammation
Laboratories
Leukocytes (neutrophilic)
Lymphocytes
Mortality
neutrophil-to-lymphocyte ratio
Neutrophils
Normal distribution
platelet-to-lymphocyte ratio
Standard deviation
Stenosis
Stents
systemic immune-inflammation index
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Summary:The study aimed to investigate and compare the predictive capacity of a systemic immune-inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) to determine a hemodynamically significant coronary artery stenosis assessed by fractional flow reserve (FFR). A total of 207 chronic coronary syndrome patients with FFR measurement were enrolled in the study. NLR, PLR and SII levels were calculated. The cut-off value of the SII (620) was associated with 78.4% sensitivity and 64.0% specificity to predict a hemodynamically significant stenosis. SII level independently predicted FFR ≤0.80. SII is an independent predictor of functionally significant coronary stenosis detected by FFR in chronic coronary syndrome patients. SII levels can predict hemodynamically severe obstruction better than NLR and PLR.
ISSN:1752-0363
1752-0371
DOI:10.2217/bmm-2020-0274