ZIF-C for targeted RNA interference and CRISPR/Cas9 based gene editing in prostate cancer

Gene therapy is highly suited for prostate cancer (PC). Metal-organic-frameworks (MOFs) are potential gene delivery systems. Target-specific cytoplasmic and nuclear knockdown in host gene expression using ZIF-C is shown for the first time through RNAi and CRISPR/Cas9 based gene editing in PC cells....

Full description

Saved in:
Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2020-12, Vol.56 (98), p.1546-1549
Main Authors: Poddar, Arpita, Pyreddy, Suneela, Carraro, Francesco, Dhakal, Sudip, Rassell, Andrea, Field, Matthew R, Reddy, T. Srinivasa, Falcaro, Paolo, Doherty, Cara M, Shukla, Ravi
Format: Article
Language:English
Subjects:
CRISPR
Gene expression
Gene therapy
Genetic modification
Green tea
Prostate cancer
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Gene therapy is highly suited for prostate cancer (PC). Metal-organic-frameworks (MOFs) are potential gene delivery systems. Target-specific cytoplasmic and nuclear knockdown in host gene expression using ZIF-C is shown for the first time through RNAi and CRISPR/Cas9 based gene editing in PC cells. A green tea phytochemical coating enhances intracellular delivery. Metal-organic-frameworks for gene therapy in prostate cancer - ZIF-C based delivery of RNA interference and CRISPR/Cas9 causes host gene expression knockdown. Coating with a green tea phytochemical enhances uptake and increases cancer cytotoxicity.
ISSN:1359-7345
1364-548X
DOI:10.1039/d0cc06241c