Association of CRP genetic variation with symptomatology, cognitive function, and circulating proinflammatory markers in civilian women with PTSD

• Published in: Journal of affective disorders 2021-01, Vol.279, p.640-649
• Main Authors: Otsuka, Takeshi, Hori, Hiroaki, Yoshida, Fuyuko, Itoh, Mariko, Lin, Mingming, Niwa, Madoka, Ino, Keiko, Imai, Risa, Ogawa, Sei, Matsui, Mie, Kamo, Toshiko, Kunugi, Hiroshi, Kim, Yoshiharu
• Format: Article
• Language: English
• Subjects: Adult; Biomarkers; C-Reactive Protein - genetics; Child; Childhood maltreatment; Cognition; Cognitive function; CRP gene; Female; Humans; Inflammation; Polymorphism, Single Nucleotide - genetics; Posttraumatic stress disorder (PTSD); Stress Disorders, Post-Traumatic - genetics; Symptomatology
• ISSN: 0165-0327; 1573-2517
• DOI: 10.1016/j.jad.2020.10.045

Background: Posttraumatic stress disorder (PTSD) has been associated with increased inflammation. C-reactive protein (CRP) is a marker of systemic inflammation, and recently, single nucleotide polymorphisms (SNPs) in the CRP gene have been associated with increased blood CRP protein levels and illness severity in PTSD patients. However, the mechanism by which the CRP SNPs are involved in PTSD remains unclear. Here we investigated the association of CRP genetic variation with blood proinflammatory protein levels, symptomatology, and cognitive function, and further explored the moderating effect of childhood maltreatment history, in adult patients with PTSD. Methods: Fifty-seven Japanese civilian women with PTSD and 73 healthy control women were enrolled. Three SNPs in the CRP gene, namely rs2794520, rs1130864, and rs3093059, were genotyped, and analyses focused on rs2794520 (T/C). Serum levels of high-sensitivity CRP (hsCRP), high-sensitivity tumor necrosis factor-α (hsTNF-α), and interleukin-6 were measured. PTSD symptoms were evaluated by the Posttraumatic Diagnostic Scale. Cognitive function was assessed by the Repeatable Battery for the Assessment of Neuropsychological Status. Childhood maltreatment history was assessed by the Childhood Trauma Questionnaire. Results: Patients with the rs2794520 CC/CT genotype, compared to those with the TT genotype, showed significantly higher levels of hsCRP (p=0.009) and hsTNF-α (p=0.001), more severe PTSD symptoms (p=0.036), and poorer cognitive function (p=0.018). A two-way analysis of variance revealed a significant genotype-by-maltreatment interaction for more severe PTSD avoidance symptom (p=0.012). Limitations: The relatively small sample size limited our findings. Conclusions: These findings may provide an insight into the etiology of PTSD from the inflammatory perspective.