Modulation of neuronal firing: what role can nanotechnology play?

[...]patch-clamp techniques provide a higher signal-to-noise ratio and target single cells but are limited to simultaneously recording couples of neurons at best. [...]this U-shaped transistor solution does not allow cell stimulation. The authors show a light-mediated depolarization of retinal gangl...

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Bibliographic Details
Published in:Nanomedicine (London, England) England), 2020-12, Vol.15 (30), p.2895-2900
Main Authors: Colombo, Elisabetta, Di Marco, Stefano, Castagnola, Valentina, DiFrancesco, Mattia Lorenzo, Maya-Vetencourt, José Fernando, Manfredi, Giovanni, Lanzani, Guglielmo, Benfenati, Fabio
Format: Article
Language:English
Subjects:
Clinical trials
Electrodes
Graphene
Magnetic fields
nanoelectrodes
Nanomaterials
Nanoparticles
Nanostructured materials
Nanotechnology
Nanowires
neural stimulation
Prostheses
Signal to noise ratio
Transistors
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Summary:[...]patch-clamp techniques provide a higher signal-to-noise ratio and target single cells but are limited to simultaneously recording couples of neurons at best. [...]this U-shaped transistor solution does not allow cell stimulation. The authors show a light-mediated depolarization of retinal ganglion cells by patch-clamp experiments on explanted retinas from a mouse model of photoreceptor degeneration (Rd1 mice), and a mild restoration of the light sensitivity through visually evoked potentials in the same animal model after subretinal implantation in vivo (14). In the sight of a safe and efficient translation of nanoparticles for neural stimulation into clinical trials, several in vitro and in vivo studies are devoted to nanostructures biodistribution and fate, blood-brain barriercrossing, and neuronal viability (15,16).
ISSN:1743-5889
1748-6963
DOI:10.2217/nnm-2020-0398