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Modulation of neuronal firing: what role can nanotechnology play?
[...]patch-clamp techniques provide a higher signal-to-noise ratio and target single cells but are limited to simultaneously recording couples of neurons at best. [...]this U-shaped transistor solution does not allow cell stimulation. The authors show a light-mediated depolarization of retinal gangl...
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| Published in: | Nanomedicine (London, England) England), 2020-12, Vol.15 (30), p.2895-2900 |
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| Main Authors: | , , , , , , , |
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| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c327t-a12384ecfbae1bc5e6cced45e29af7916c14b449108eee9f199b7873319b8efa3 |
| container_end_page | 2900 |
| container_issue | 30 |
| container_start_page | 2895 |
| container_title | Nanomedicine (London, England) |
| container_volume | 15 |
| creator | Colombo, Elisabetta Di Marco, Stefano Castagnola, Valentina DiFrancesco, Mattia Lorenzo Maya-Vetencourt, José Fernando Manfredi, Giovanni Lanzani, Guglielmo Benfenati, Fabio |
| description | [...]patch-clamp techniques provide a higher signal-to-noise ratio and target single cells but are limited to simultaneously recording couples of neurons at best. [...]this U-shaped transistor solution does not allow cell stimulation. The authors show a light-mediated depolarization of retinal ganglion cells by patch-clamp experiments on explanted retinas from a mouse model of photoreceptor degeneration (Rd1 mice), and a mild restoration of the light sensitivity through visually evoked potentials in the same animal model after subretinal implantation in vivo (14). In the sight of a safe and efficient translation of nanoparticles for neural stimulation into clinical trials, several in vitro and in vivo studies are devoted to nanostructures biodistribution and fate, blood-brain barriercrossing, and neuronal viability (15,16). |
| doi_str_mv | 10.2217/nnm-2020-0398 |
| format | article |
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| ispartof | Nanomedicine (London, England), 2020-12, Vol.15 (30), p.2895-2900 |
| issn | 1743-5889 1748-6963 |
| language | eng |
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| source | Open Access: PubMed Central |
| subjects | Clinical trials Electrodes Graphene Magnetic fields nanoelectrodes Nanomaterials Nanoparticles Nanostructured materials Nanotechnology Nanowires neural stimulation Prostheses Signal to noise ratio Transistors |
| title | Modulation of neuronal firing: what role can nanotechnology play? |
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