Advances in the Management of Pediatric Sarcomas

Purpose of Review The prognosis of pediatric patients who present with metastatic or recurrent sarcomas remains poor. In this review, we summarize the advances in the management of metastatic and relapsed pediatric sarcoma by highlighting recent and future clinical trials. Recent Findings Research i...

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Bibliographic Details
Published in:Current oncology reports 2021, Vol.23 (1), p.3-3, Article 3
Main Authors: Hernandez Tejada, Fiorela N., Zamudio, Alejandro, Marques-Piubelli, Mario L., Cuglievan, Branko, Harrison, Douglas
Format: Article
Language:English
Subjects:
Clinical trials
Medicine
Medicine & Public Health
Metastases
Metastasis
Oncology
Patients
Pediatrics
Sarcoma
Sarcomas (SR Patel
Section Editor
Topical Collection on Sarcomas
Tumors
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Summary:Purpose of Review The prognosis of pediatric patients who present with metastatic or recurrent sarcomas remains poor. In this review, we summarize the advances in the management of metastatic and relapsed pediatric sarcoma by highlighting recent and future clinical trials. Recent Findings Research into the identification of novel therapies for refractory pediatric sarcomas continues to advance. Outcomes have not improved in several decades underlying a need for improved understanding of the biology behind these tumors and the identification of novel therapeutic molecular targets that can be exploited pharmacologically. Multiple challenges remain for novel therapy in sarcomas such as the selection of effective targets, management of toxicities, and the tumor microenvironment. Summary Many unique challenges remain in the treatment of patients with refractory pediatric sarcomas. Multiple strategies and targets are under investigation that hold promise.
ISSN:1523-3790
1534-6269
DOI:10.1007/s11912-020-00995-8