Prediction of optimal contrast times post-imaging agent administration to inform personalized fluorescence-guided surgery

• Published in: Journal of biomedical optics 2020-11, Vol.25 (11), p.116005-116005
• Main Authors: Sadeghipour, Negar, Rangnekar, Aakanksha, Folaron, Margaret R, Strawbridge, Rendall R, Samkoe, Kimberley S, Davis, Scott C, Tichauer, Kenneth M
• Format: Article
• Language: English
• Subjects: Animals; Contrast Media; Fluorescence; Fluorescent Dyes; Humans; Imaging; Magnetic Resonance Imaging; Mice; Neoplasms - diagnostic imaging; Neoplasms - drug therapy
• ISSN: 1083-3668; 1560-2281
• DOI: 10.1117/1.JBO.25.11.116005

Significance: Fluorescence guidance in cancer surgery (FGS) using molecular-targeted contrast agents is accelerating, yet the influence of individual patients’ physiology on the optimal time to perform surgery post-agent-injection is not fully understood. Aim: Develop a mathematical framework and analytical expressions to estimate patient-specific time-to-maximum contrast after imaging agent administration for single- and paired-agent (coadministration of targeted and control agents) protocols. Approach: The framework was validated in mouse subcutaneous xenograft studies for three classes of imaging agents: peptide, antibody mimetic, and antibody. Analytical expressions estimating time-to-maximum-tumor-discrimination potential were evaluated over a range of parameters using the validated framework for human cancer parameters. Results: Correlations were observed between simulations and matched experiments and metrics of tumor discrimination potential (p