Enhancement of Anticancer Efficacy and Tumor Penetration of Sorafenib by Ionic Liquids

Ionic liquids (ILs) possess unique solvation and biological properties for drug delivery. Choline and geranic acid (CAGE) in particular, has been successfully formulated to orally deliver insulin and hydrophobic therapeutics such as sorafenib (SRF). However, relatively little is known about the effe...

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Bibliographic Details
Published in:Advanced healthcare materials 2021-01, Vol.10 (2), p.e2001455-n/a
Main Authors: Shi, Yujie, Zhao, Zongmin, Peng, Kevin, Gao, Yongsheng, Wu, Debra, Kim, Jayoung, Mitragotri, Samir
Format: Article
Language:English
Subjects:
Anticancer properties
Apoptosis
Biological properties
Caco-2 Cells
Cages
cell cycles
Choline
Drug delivery
Drug Delivery Systems
Epithelium
Exocytosis
Humans
Hydrophobic and Hydrophilic Interactions
Hydrophobicity
Inhibitor drugs
Insulin
Intestine
Intracellular
Ionic Liquids
Ions
Penetration
Solvation
sorafenib
Sorafenib - pharmacology
Targeted cancer therapy
Tumors
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Summary:Ionic liquids (ILs) possess unique solvation and biological properties for drug delivery. Choline and geranic acid (CAGE) in particular, has been successfully formulated to orally deliver insulin and hydrophobic therapeutics such as sorafenib (SRF). However, relatively little is known about the effect of CAGE on intracellular delivery of drugs. Here the effect of low‐concentration CAGE (
ISSN:2192-2640
2192-2659
DOI:10.1002/adhm.202001455