The effects of aging and disease duration on cognition in multiple sclerosis

•Aging is a major factor that influences cognitive functions in MS.•A trend of disease duration influencing information processing speed is observed.•Results revealed no interaction between age and presence ofMS on memory functions. Multiple sclerosis (MS) is a disease of the central nervous system...

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Bibliographic Details
Published in:Brain and cognition 2020-12, Vol.146, p.105650-105650, Article 105650
Main Authors: Tremblay, A., Charest, K., Brando, E., Roger, E., Duquette, P., Rouleau, I.
Format: Article
Language:English
Subjects:
Adult
Age
Aged
Aging
Central nervous system
Cognition
Cognition & reasoning
Cognitive ability
Disease duration
Executive function
Geriatrics
Humans
Information processing
Life span
Memory
Middle Aged
Multiple sclerosis
Multiple Sclerosis - complications
Neuropsychological Tests
Quality of Life
Short term memory
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Summary:•Aging is a major factor that influences cognitive functions in MS.•A trend of disease duration influencing information processing speed is observed.•Results revealed no interaction between age and presence ofMS on memory functions. Multiple sclerosis (MS) is a disease of the central nervous system that can interfere with cognitive functions. The purpose of this study is to document the impact of MS, aging and disease duration on cognitive functioning as both life expectancy and incidence of the disease among persons with MS (PwMS) aged 50 years and over (late-onset MS) are increasing in the last two decades. Exhaustive neuropsychological evaluation was performed in 84 PwMS (30 young, 30 elderly adult-onset, 25 elderly late-onset) and 50 control participants (25 young, 24 elderly). ANCOVAs and hierarchical linear regressions were used to meet the objectives. Interaction effects were found between age and presence of MS on higher executive function and information processing speed/working memory. After controlling for confounding variables (fatigue, quality of life, depression, MS course, comorbidity), results demonstrated an important role of age on all cognitive functions but only a trend of disease duration on information processing speed/working memory. Decline in higher executive functions and information processing speed/working memory in aging is accentuated by the presence of MS, but the impact of age and MS on memory are independent. Age appears to be the variable having the most important role on cognition.
ISSN:0278-2626
1090-2147
DOI:10.1016/j.bandc.2020.105650