Texture analysis of T2-weighted MRI predicts SDH mutation in paraganglioma

Purpose Texture analysis can quantify sophisticated imaging characteristics. We hypothesized that 2D textures computed with T2-weighted and post-contrast T1-weighted MRI can predict succinate dehydrogenase ( SDH ) mutation status in head and neck paragangliomas. Methods Our retrospective study inclu...

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Bibliographic Details
Published in:Neuroradiology 2021-04, Vol.63 (4), p.547-554
Main Authors: Naganawa, Shotaro, Kim, John, Yip, Stephen S. F., Ota, Yoshiaki, Srinivasan, Ashok, Moritani, Toshio
Format: Article
Language:English
Subjects:
Computation
Dependence
Head and neck
Head-Neck-ENT Radiology
Imaging
Magnetic resonance imaging
Medicine
Medicine & Public Health
Mutants
Mutation
Neuroendocrine tumors
Neurology
Neuroradiology
Neurosciences
Neurosurgery
Nonuniformity
Paraganglioma
Radiology
Statistical analysis
Succinate dehydrogenase
Texture
Tumors
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Summary:Purpose Texture analysis can quantify sophisticated imaging characteristics. We hypothesized that 2D textures computed with T2-weighted and post-contrast T1-weighted MRI can predict succinate dehydrogenase ( SDH ) mutation status in head and neck paragangliomas. Methods Our retrospective study included 21 patients (1 to 4 tumors/patient) with 24 pathologically proven paragangliomas in the head and neck. Fourteen lesions (58%) were SDH mutation-positive. All patients underwent T2-weighted and post-contrast T1-weighted MRI sequences. Three 2D texture features of dependence non-uniformity normalized (DNN), small dependence high gray level emphasis (SDHGLE), and small dependence low gray level emphasis (SDLGLE) were calculated. Computed textures between SDH mutants and non-mutants were compared using Mann-Whitney U test. Area under the receiver operating characteristic (AUROC) curve was used to quantify the predictive power of each texture. Results Only T2-based SDLGLE was statistically significant ( p  = 0.048), and AUROC was 0.71. Diagnostic accuracy was 70.8%. Conclusion 2D texture parameter of T2-based SDLGLE predicts SDH mutation in head and neck paragangliomas. This noninvasive technique can potentially facilitate further genetic workup.
ISSN:0028-3940
1432-1920
DOI:10.1007/s00234-020-02607-5