Tumors in the cauda equina: A SEER analysis of tumor types and predictors of outcome

•This is first dedicated analysis of primary cauda equina tumors (PCET) reported in SEER.•PCET display a wide histological variety-schwannomas and ependymomas are most common.•Definitive surgical resection with adjuvant radiation in well selected patients is the standard therapy.•Gross total resecti...

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Bibliographic Details
Published in:Journal of clinical neuroscience 2020-11, Vol.81, p.227-233
Main Authors: Das, Saurav, John, Kevin Denny, Urevick, Alexander Joseph, Yusuf, Mehran Behruj, Wang, Dengzhi, Ugiliweneza, Beatrice, Woo, Shiao Y., Skirboll, Stephen, Boakye, Maxwell
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Cauda equina
Cauda Equina - pathology
Child
Child, Preschool
Ependymoma - diagnosis
Ependymoma - mortality
Ependymoma - surgery
Female
Humans
Infant
Infant, Newborn
Male
Middle Aged
Neurilemmoma - diagnosis
Neurilemmoma - mortality
Neurilemmoma - surgery
Predictive Value of Tests
Primary cauda equina tumors
Retrospective Studies
SEER
SEER Program - trends
Spinal Cord Neoplasms - diagnosis
Spinal Cord Neoplasms - mortality
Spinal Cord Neoplasms - surgery
Spinal cord tumors
Survival Rate - trends
Treatment Outcome
Young Adult
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Summary:•This is first dedicated analysis of primary cauda equina tumors (PCET) reported in SEER.•PCET display a wide histological variety-schwannomas and ependymomas are most common.•Definitive surgical resection with adjuvant radiation in well selected patients is the standard therapy.•Gross total resection of tumor improves survival, and patients with 50 years or older age at diagnosis experience higher mortality. Caudaequinatumors are histologically diverse. International Classification of Diseases for Oncology (ICD-O3) confers dedicated site code (C72. 1) for cauda equina. This code is excluded during analyses of other primary spinal cord tumors. In this retrospective study, the Surveillance, Epidemiology and End Results (SEER) data for primary cauda equina tumors (PCET, C72. 1) excluding the tumors of spinal meninges (C70. 1) from 1992 to 2015 were reviewed. Demographic characteristics, tumor types, and clinical outcomes were analyzed using univariable analysis. Overall survival was estimated using Kaplan-Meier methods and compared for age, histology and treatment type. 293 patients with PCET met inclusion criteria. The most common tumors comprised schwannoma (32%), myxopapillary ependymoma (21%), malignant ependymoma (22%). The median age at diagnosis was 50 years (range 
ISSN:0967-5868
1532-2653
DOI:10.1016/j.jocn.2020.09.068