Multi‐wavelength, handheld laser speckle imaging for skin evaluation

Objective A handheld device was developed and qualified for in vivo human skin evaluation using laser speckle imaging technology. Methods Each laser speckle device prototype allows the choice of up to three different laser wavelengths in the range of 400 nm to 800 nm in total. Speckle pattern analys...

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Bibliographic Details
Published in:Skin research and technology 2021-07, Vol.27 (4), p.486-493
Main Authors: Zieger, Michael, Kaatz, Martin, Springer, Steffen, Riesenberg, Rainer, Wuttig, Andreas, Kanka, Mario, Stanca, Sarmiza, Reble, Carina, Khazaka, Georg, Sieg, Robin, De Gregorio, Marco, Sattler, Martin, Fischer, Frank
Format: Article
Language:English
Subjects:
Aging
Basal cell carcinoma
Fractal geometry
handheld
Imaging
In vivo methods and tests
laser speckle imaging
Lasers
non‐invasive human skin diagnostics
Pattern analysis
Prototypes
skin ageing
Skin cancer
Skin diseases
Speckle patterns
Wavelengths
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Summary:Objective A handheld device was developed and qualified for in vivo human skin evaluation using laser speckle imaging technology. Methods Each laser speckle device prototype allows the choice of up to three different laser wavelengths in the range of 400 nm to 800 nm in total. Speckle pattern analysis gives various speckle parameters, for example, speckle contrast, speckle size, speckle modulation or fractal dimension. The developed laser speckle device prototypes were evaluated investigating three skin issues. Results We receive reproducible results from the speckle imaging device. For skin ageing, we found significant changes within three age groups. The effect of a methyl nicotinate treatment was clearly visible and quantifiable using a moorFLPI device as well as our speckle imaging device. In terms of basal cell carcinoma diagnosis, we found significant differences between normal and diseased skin, even though the number of samples was limited. Conclusion As shown with first application examples, it was possible to demonstrate the potential of the method for skin evaluation in vivo.
ISSN:0909-752X
1600-0846
DOI:10.1111/srt.12959