Tumor-infiltrating B cell is associated with the control of progression of gastric cancer

This study aimed to further explore the clinicopathological correlation of B cell infiltration in gastric cancer (GC) and its impact on prognostic. By immunohistochemical method, CD20+ B cells, CD3+ T cells, CD66b+ tumor-associated neutrophils, CD163+ tumor-associated macrophages, and CD57+ natural...

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Bibliographic Details
Published in:Immunologic research 2021-02, Vol.69 (1), p.43-52
Main Authors: Ni, Zhonglin, Xing, Dong, Zhang, Teming, Ding, Ning, Xiang, Dan, Zhao, Zhiguang, Qu, Jinmiao, Hu, Changyuan, Shen, Xian, Xue, Xiangyang, Zhou, Jie
Format: Article
Language:English
Subjects:
Allergology
Antigens, CD20 - metabolism
B-Lymphocyte Subsets - immunology
B-Lymphocytes - immunology
Biomedical and Life Sciences
Biomedicine
Cancer
Carcinogenesis
CD163 antigen
CD20 antigen
CD3 antigen
CD4 antigen
CD57 antigen
CD8 antigen
Disease Progression
Gastric cancer
Gastric Mucosa - pathology
Humans
Immunohistochemistry
Immunologic Memory
Immunological memory
Immunology
Infiltration
Internal Medicine
Leukocytes (neutrophilic)
Lymph nodes
Lymphocytes
Lymphocytes B
Lymphocytes T
Lymphocytes, Tumor-Infiltrating - immunology
Macrophages
Medical prognosis
Medicine/Public Health
Memory cells
Metastases
Natural killer cells
Neoplasm Staging
Original Article
Plasma cells
Prognosis
Regression analysis
Stomach Neoplasms - diagnosis
Stomach Neoplasms - immunology
Stomach Neoplasms - mortality
Survival
Survival Analysis
T-Lymphocytes - immunology
Tissues
Tumors
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Summary:This study aimed to further explore the clinicopathological correlation of B cell infiltration in gastric cancer (GC) and its impact on prognostic. By immunohistochemical method, CD20+ B cells, CD3+ T cells, CD66b+ tumor-associated neutrophils, CD163+ tumor-associated macrophages, and CD57+ natural killer cells were analyzed in consecutive sections of 584 GC tissues and 69 normal adjacent tissues. Kaplan–Meier and Cox regression analyses determined the relationship between clinical relevance or prognosis and B cell infiltration. The correlation between total B cell infiltration and various T cell subtype infiltration in GC tissues from 407 patients in the TCGA data was also analyzed. Kaplan–Meier and Cox regression analyses determined the effects of total B cell infiltration and various B cell subtype infiltration on the prognosis of patients with GC. The infiltration level of CD20+ B cells was positively correlated with that of T cells (risk ratio [RR] = 0.0930), especially CD4+ T cells and CD8+ T cells ( P  
ISSN:0257-277X
1559-0755
DOI:10.1007/s12026-020-09167-z