Effects of Hsian-tsao ( Hemsl.) extracts and its polysaccharides on the promotion of wound healing under diabetes-like conditions

The aim of the study was to evaluate the effects of Hsian-tsao ( Mesona procumbens Hemsl.) and its polysaccharides on impaired wound healing in diabetes. The results indicate that ethanol extracts of Hsian-tsao (EE) and crude polysaccharides from water extracts of Hsian-tsao (WEP) had strong inhibit...

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Published in:Food & function 2021-01, Vol.12 (1), p.119-132
Main Authors: Fan, Siao-Ling, Lin, Jer-An, Chen, Sheng-Yi, Lin, Jia-Hong, Lin, Hsin-Tang, Chen, Ying-Yin, Yen, Gow-Chin
Format: Article
Language:English
Subjects:
Diabetes
Diabetes mellitus
Ethanol
Fibroblasts
Gelatinase B
Glycosylation
Inflammation
Macrophage inflammatory protein
Macrophages
Metalloproteinase
Phagocytosis
Polysaccharides
Proteins
Pseudomonas aeruginosa
Pyruvaldehyde
Reactive oxygen species
Saccharides
Tissue inhibitor of metalloproteinase 1
Wound healing
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Summary:The aim of the study was to evaluate the effects of Hsian-tsao ( Mesona procumbens Hemsl.) and its polysaccharides on impaired wound healing in diabetes. The results indicate that ethanol extracts of Hsian-tsao (EE) and crude polysaccharides from water extracts of Hsian-tsao (WEP) had strong inhibitory effects on methylglyoxal (MG)-induced glycation and reactive oxygen species (ROS) production. EE and WEP also decreased MG-induced inflammation-related factors in RAW 264.7 macrophages and restored MG-impaired wound-healing factors in 3T3-L1 fibroblasts. Furthermore, EE and WEP were found to dose-dependently enhance the MG-impaired phagocytosis of Staphylococcus aureus and Pseudomonas aeruginosa by macrophages. Excitingly, EE and WEP significantly enhanced wound healing on the dorsal skin through regulation of macrophage inflammatory protein-2 (MIP-2), metalloproteinase-9 (MMP-9), and tissue inhibitor of metalloproteinase-1 (TIMP-1) protein expressions in diabetic mice, as evidenced by the percentage reduction in wound surface area and the results of histopathologic scoring analysis. In conclusion, these results suggest that Hsian-tsao extract and its polysaccharides might be utilized in alternative natural therapy to promote wound healing in diabetic individuals. Hsian-tsao extracts and its polysaccharides accelerate wound healing in cell models and diabetic mice.
ISSN:2042-6496
2042-650X
DOI:10.1039/d0fo02180f