Low-field benchtop NMR spectroscopy as a potential non-stationary tool for point-of-care urinary metabolite tracking in diabetic conditions

We describe the advantages and diagnostic/prognostic significance of low-field, near-portable benchtop NMR spectrometers for the multicomponent metabolomics analysis of targeted and untargeted urinary biomarkers (≥15) in type 2 diabetes patients. Implementation of these facilities at ‘point-of-care’...

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Bibliographic Details
Published in:Diabetes research and clinical practice 2021-01, Vol.171, p.108554-108554, Article 108554
Main Authors: Edgar, Mark, Percival, Benita C., Gibson, Miles, Jafari, Fereshteh, Grootveld, Martin
Format: Article
Language:English
Subjects:
Adult
Biomarkers
Case-Control Studies
Diabetes Mellitus, Type 2 - urine
Female
Humans
Magnetic Resonance Spectroscopy - methods
Male
Metabolomics - methods
Middle Aged
NMR-based metabolomics
Non-stationary benchtop 60 MHz NMR analysis
Point-of-Care Systems - standards
Prediabetes
Prognosis
Type 2 diabetes
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Summary:We describe the advantages and diagnostic/prognostic significance of low-field, near-portable benchtop NMR spectrometers for the multicomponent metabolomics analysis of targeted and untargeted urinary biomarkers (≥15) in type 2 diabetes patients. Implementation of these facilities at ‘point-of-care’ clinical sites may yield valuable advantages for the sequential monitoring of diabetic and prediabetic individuals.
ISSN:0168-8227
1872-8227
DOI:10.1016/j.diabres.2020.108554