Cladodes from Nopalea cochenillifera (L.) Salm-Dyck (Cactaceae) attenuate postprandial glycaemia without markedly influencing α-glucosidase activity

Although the cladodes of are used in Mexican traditional medicine to treat diabetes and various other diseases, its antihyperglycaemic properties, phenolic content, and antioxidant activity are not well documented. Thus, we determined the activity of a single dose of fresh, blended cladodes on postp...

Full description

Saved in:
Bibliographic Details
Published in:Natural product research 2022-02, Vol.36 (4), p.1105-1108
Main Authors: Magaña-Cerino, Jesús Miguel, Guzmán, Tereso Jovany, Soto-Luna, Irma Catalina, Betanzos-Cabrera, Gabriel, Gurrola-Díaz, Carmen Magdalena
Format: Article
Language:English
Subjects:
Acarbose
alpha-Glucosidases - metabolism
Animals
Antioxidants
Blood Glucose
Cactaceae - chemistry
Diabetes mellitus
Glucosidase
Hypoglycemic Agents - pharmacology
Nopalea cochenillifera
Phenolic compounds
Phenols
Plant Extracts - pharmacology
Rats
α-Glucosidase
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Although the cladodes of are used in Mexican traditional medicine to treat diabetes and various other diseases, its antihyperglycaemic properties, phenolic content, and antioxidant activity are not well documented. Thus, we determined the activity of a single dose of fresh, blended cladodes on postprandial glycaemia in rats after a starch load. We prepared a methanolic extract of cladodes and measured its phenolic content, antioxidant capacity, and α-glucosidase inhibitory activity. The antihyperglycaemic effect of blended cladodes was similar to that of acarbose when considering the changes in glucose levels from baseline. Furthermore, the methanolic extract contained a considerable amount of phenolic compounds and exhibited antioxidant activity in the DPPH assay, but did not markedly inhibit α-glucosidase and had a low antioxidant effect in the ABTS test.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2020.1851223