The Finnish Diabetes Risk Score (FINDRISC), incident diabetes and low-grade inflammation

•The FINDRISC does not use laboratory tests.•Low grade inflammation is associated with T2DM onset.•The FINDRISC was associated with current and incident T2DM.•The FINDRISC was associated with current and incident low grade inflammation.•The FINDRISC showed good discrimination for incident T2DM but n...

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Bibliographic Details
Published in:Diabetes research and clinical practice 2021-01, Vol.171, p.108558-108558, Article 108558
Main Authors: Pesaro, Antonio E., Bittencourt, Márcio Sommer, Franken, Marcelo, Carvalho, Jose A.M., Bernardes, Daniel, Tuomilehto, Jaakko, Santos, Raul D.
Format: Article
Language:English
Subjects:
Adult
Cardiovascular disease
Cross-Sectional Studies
Diabetes
Diabetes Mellitus, Type 2 - epidemiology
Female
FINDRISC
Finland
Humans
Incidence
Inflammation
Inflammation - complications
Male
Risk Factors
Risk prediction
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Summary:•The FINDRISC does not use laboratory tests.•Low grade inflammation is associated with T2DM onset.•The FINDRISC was associated with current and incident T2DM.•The FINDRISC was associated with current and incident low grade inflammation.•The FINDRISC showed good discrimination for incident T2DM but not for inflammation in Brazilians. The FINDRISC was created to predict the development of type 2 diabetes mellitus (T2DM). Since T2DM associates with inflammation we evaluated if the FINDRISC could predict either current or incident T2DM, and elevated high sensitivity C-reactive protein (hs-CRP). 41,880 people (age 41.9 ± 9.7 years; 31% female) evaluated between 2008 and 2016 were included. First, the cross-sectional association between the FINDRISC with presence of either T2DM or hs-CRP ≥ 2.0 mg/L was tested. After a 5 ± 3 years follow-up we tested the score predictive value for incident T2DM and inflammation in respectively 10,559 individuals without diabetes and in a subset of 2,816 individuals having no elevated hs-CRP at baseline. In the cross sectional analysis the FINDRISC was associated with both T2DM (OR 1.24, 95% CI: 1.23–1.26, P 
ISSN:0168-8227
1872-8227
DOI:10.1016/j.diabres.2020.108558