Pyrazolo[1,5-a]pyrimidine based Trk inhibitors: Design, synthesis, biological activity evaluation

[Display omitted] •Novel pyrazolo[1,5-a]pyrimidine derivatives were designed and synthesized.•TrkA, TrkB and TrkC inhibitory activity were evaluated.•Compounds 8a, 8f, 9a, 9b and 9f (IC50 

Saved in:
Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2021-01, Vol.31, p.127712-127712, Article 127712
Main Authors: Zhang, Yongjie, Liu, Yan, Zhou, Ying, Zhang, Qing, Han, Tianfu, Tang, Chunlei, Fan, Weizheng
Format: Article
Language:English
Subjects:
Anticancer
Design and synthesis
Molecular docking
Tropomyosin receptor kinases
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:[Display omitted] •Novel pyrazolo[1,5-a]pyrimidine derivatives were designed and synthesized.•TrkA, TrkB and TrkC inhibitory activity were evaluated.•Compounds 8a, 8f, 9a, 9b and 9f (IC50 
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2020.127712