Blood cadmium levels as a marker for early lung cancer detection

•Cadmium level is strong associated with occurrence of the lung cancer.•Blood cadmium level may be valuable marker for early detection of lung cancers.•The assessment of blood cadmium level can help with the early detection of lung cancer among former smokers (OR = 16.8). We assessed whether blood c...

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Published in:Journal of trace elements in medicine and biology 2021-03, Vol.64, p.126682-126682, Article 126682
Main Authors: Lener, Marcin R., Reszka, Edyta, Marciniak, Wojciech, Lesicka, Monika, Baszuk, Piotr, Jabłońska, Ewa, Białkowska, Katarzyna, Muszyńska, Magdalena, Pietrzak, Sandra, Derkacz, Róża, Grodzki, Tomasz, Wójcik, Janusz, Wojtyś, Małgorzata, Dębniak, Tadeusz, Cybulski, Cezary, Gronwald, Jacek, Kubisa, Bartosz, Pieróg, Jarosław, Waloszczyk, Piotr, Scott, Rodney J., Jakubowska, Anna, Narod, Steven A., Lubiński, Jan
Format: Article
Language:English
Subjects:
Cadmium
Detection marker
Lung cancer
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Summary:•Cadmium level is strong associated with occurrence of the lung cancer.•Blood cadmium level may be valuable marker for early detection of lung cancers.•The assessment of blood cadmium level can help with the early detection of lung cancer among former smokers (OR = 16.8). We assessed whether blood cadmium levels were associated with incident lung cancer and could be used in the context of a screening program for early-stage lung cancer. We measured blood cadmium levels among 205 lung cancer patients and 205 matched controls. Cases and controls were matched for sex, age and smoking history (total pack-years, years since cessation for former smokers). The odds ratio for those in the highest quartile of cadmium level (versus lowest) was four-fold (OR = 4.41, 95 % CI:2.01–9.67, p 
ISSN:0946-672X
1878-3252
DOI:10.1016/j.jtemb.2020.126682