Applications of ion level nanosensors for neuroscience research

Ion activities are tightly associated with brain physiology, such as intracranial cell membrane potential, neural activity and neuropathology. Thus, monitoring the ion levels in the brain is of great significance in neuroscience research. Recently, nanosensors have emerged as powerful tools for moni...

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Bibliographic Details
Published in:Nanomedicine (London, England) England), 2020-12, Vol.15 (29), p.2871-2881
Main Authors: Wei, Min, Lin, Peihua, Chen, Ying, Lee, Ji Young, Zhang, Lingxiao, Li, Fangyuan, Ling, Daishun
Format: Article
Language:English
Subjects:
Brain research
Disease
Epilepsy
Homeostasis
ion detection
Ligands
membrane potential
Nanocomposites
Nanoparticles
nanosensors
neural activity
Neurological disorders
neuropathology
Neurosciences
Physiology
Quantum dots
Sensors
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Summary:Ion activities are tightly associated with brain physiology, such as intracranial cell membrane potential, neural activity and neuropathology. Thus, monitoring the ion levels in the brain is of great significance in neuroscience research. Recently, nanosensors have emerged as powerful tools for monitoring brain ion levels and dynamics. With controllable structures and functions, nanosensors have been intensively used for monitoring neural activity and cell function and can be used in disease diagnosis. Here, we summarize the recent advances in the design and application of ion level nanosensors at different physiological levels, aiming to draw a connection of the interrelated intracranial ion activities. Furthermore, perspectives on the rationally designed ion level nanosensors in understanding the brain functions are highlighted.
ISSN:1743-5889
1748-6963
DOI:10.2217/nnm-2020-0320