Investigation and identification of the multiple components of Rheum officinale Baill. using ultra‐high‐performance liquid chromatography coupled with quadrupole‐time‐of‐flight tandem mass spectrometry and data mining strategy

Rheum officinale Baill. is a traditional Chinese medicine that has long been used for eliminating body heat, cooling and detoxifying blood, removing blood stasis and promoting menstruation, and clearing away heat‐dampness to eliminate jaundice. Comprehensive and systematic structural identification...

Full description

Saved in:
Bibliographic Details
Published in:Journal of separation science 2021-02, Vol.44 (3), p.681-690
Main Authors: Yao, Min, Li, Junmao, He, Mingzhen, Ouyang, Hui, Ruan, Lulu, Huang, Xiaofang, Rao, Yifei, Yang, Shilin, Zhou, Xiang, Bai, Jiqing
Format: Article
Language:English
Subjects:
Anthraquinones
Blood
chemical profiling,data mining strategy
Chromatography
Complex compounds
Data mining
High performance liquid chromatography
Mass spectrometry
Menstruation
Moisture content
Phenolic acids
Quadrupoles
quadrupole‐time‐of‐flight
Quality control
Scientific imaging
Spectroscopy
Traditional Chinese medicine
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Rheum officinale Baill. is a traditional Chinese medicine that has long been used for eliminating body heat, cooling and detoxifying blood, removing blood stasis and promoting menstruation, and clearing away heat‐dampness to eliminate jaundice. Comprehensive and systematic structural identification of the components of Rheum officinale Baill. remains a challenge. An appropriate analytical method needs to be established for the comprehensive investigation and identification of the chemical constituents in Rheum officinale Baill. extract. In this study, a new systematic approach using ultra high performance liquid chromatography with quadrupole time‐of‐flight mass spectrometry in conjunction with a data mining strategy was developed to screen the targeted and nontargeted components of Rheum officinale Baill. A total of 124 compounds were identified in the Rheum officinale Baill. extract including 31 acylglucosides, 9 phenolic acids, 26 tannins, 53 anthraquinones, and 5 other compounds. Note that 55 of these compounds were reported for the first time here. In conclusion, in this study, we devised an efficient and systematic method for detecting complex compounds and have used it here to provide a foundation for future research into bioactive ingredients and quality control of Rheum officinale Baill. extract.
ISSN:1615-9306
1615-9314
DOI:10.1002/jssc.202000735