Can palatovaginal canal be the site of origin of juvenile nasopharyngeal angiofibroma?

Juvenile nasopharyngeal angiofibroma (JNA) is the most common benign tumor of the nasopharynx. For reasons unknown, this tumor is found almost always in male population. However, site of origin of JNA is still an enigma. Previously, JNA was considered to arise from the superior aspect of sphenopalat...

Full description

Saved in:
Bibliographic Details
Published in:Medical hypotheses 2020-11, Vol.144, p.110300-110300, Article 110300
Main Authors: Kairo, A.K., Kumar, R., Sharma, S.C.
Format: Article
Language:English
Subjects:
Angiofibroma
Female
Humans
Juvenile nasopharyngeal angiofibroma
Male
Nasopharyngeal Neoplasms
Nasopharyngeal tumor
Nasopharynx
Palatovaginal canal
Skull base tumor
Vidian canal
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Juvenile nasopharyngeal angiofibroma (JNA) is the most common benign tumor of the nasopharynx. For reasons unknown, this tumor is found almost always in male population. However, site of origin of JNA is still an enigma. Previously, JNA was considered to arise from the superior aspect of sphenopalatine foramen. Over last decade, the vidian canal was considered to be the more specific and likely site of origin. However, based on our observations, we believe this hypothesis to be anomalous as it does not explain major blood supply, pattern of skull base erosion in early stage of tumor and newer studies on electron microscopic and immunopathological findings. To explain these anomalies, we hypothesize the site of origin to be palato-vaginal canal.
ISSN:0306-9877
1532-2777
DOI:10.1016/j.mehy.2020.110300