The rationale behind implant coatings to promote osteointegration, bone healing or regeneration

•The clinical problem in orthopedic and trauma surgery and explain the four “osteos-”essential for implant integration and bone regeneration.•Present examples of coatings that are used in different orthopedic indications.•Finally raise the awareness of coating and translational requirements. Implant...

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Bibliographic Details
Published in:Injury 2021-06, Vol.52, p.S106-S111
Main Authors: Borcherding, Kai, Schmidmaier, Gerhard, Hofmann, Gunther O., Wildemann, Britt
Format: Article
Language:English
Subjects:
Arthroplasty
Coating
Defect
Fracture healing
Osteoconduction
Osteogenesis
Osteoinduction
Osteointegration
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Summary:•The clinical problem in orthopedic and trauma surgery and explain the four “osteos-”essential for implant integration and bone regeneration.•Present examples of coatings that are used in different orthopedic indications.•Finally raise the awareness of coating and translational requirements. Implant loosening, bone healing failure, implant-associated infections, and large bony defects remain challenges in orthopedic surgery. Implant surface modifications and coatings are being developed to promote osteointegration, prevent colonization by bacteria, and release bioactive factors. The following mini-review briefly discusses the clinical problem, explains the four “osteos”, presents examples of coatings used for different orthopedic indications, and finally raises awareness of the coating and translational requirements.
ISSN:0020-1383
1879-0267
DOI:10.1016/j.injury.2020.11.050