Impact of restricting procalcitonin measurements in a Swiss tertiary-care hospital on antibiotic use, clinical outcomes, and costs: An interrupted time-series analysis

We evaluated the impact of a restriction of procalcitonin measurements on antibiotic use, length of stay, mortality, and cost in a Swiss tertiary-care hospital using interrupted time-series analysis. There was no significant change in level or slope for rates of antibiotic consumption, and costs dec...

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Bibliographic Details
Published in:Infection control and hospital epidemiology 2021-07, Vol.42 (7), p.890-892
Main Authors: Abbas, Mohamed, Vernaz, Nathalie, von Dach, Elodie, Vuilleumier, Nicolas, Harbarth, Stephan J., Huttner, Benedikt D.
Format: Article
Language:English
Subjects:
Antibiotics
Antimicrobial agents
Clinical outcomes
Cost control
Diagnostic tests
Emergency medical care
Foreign exchange rates
Laboratories
Mortality
Nursing
Patients
Pediatrics
Pneumonia
Quasi-experimental methods
Reagents
Sepsis
Time series
Trends
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Summary:We evaluated the impact of a restriction of procalcitonin measurements on antibiotic use, length of stay, mortality, and cost in a Swiss tertiary-care hospital using interrupted time-series analysis. There was no significant change in level or slope for rates of antibiotic consumption, and costs decreased considerably, by ~54,488 CHF (US$55,714) per month.
ISSN:0899-823X
1559-6834
DOI:10.1017/ice.2020.1314