Cerebral oxygenation and circulatory parameters during pressure-controlled vs volume-targeted mechanical ventilation in extremely preterm infants

Respiratory distress syndrome (RDS) is the most common cause of respiratory failure of infants born prematurely with very low birth weight (VLBW). Essential elements of RDS management include ventilatory support and endotracheal administration of a surfactant. To assess the effect of volume-targeted...

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Bibliographic Details
Published in:Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2020-11, Vol.29 (11), p.1325-1329
Main Authors: Bugiera, Michalina, Szczapa, Tomasz, Sowińska, Anna, Roehr, Charles Christoph, Szymankiewicz-Bręborowicz, Marta
Format: Article
Language:English
Subjects:
Humans
Infant, Extremely Premature
Infant, Newborn
Intermittent Positive-Pressure Ventilation
Prospective Studies
Respiration, Artificial
Tidal Volume
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Summary:Respiratory distress syndrome (RDS) is the most common cause of respiratory failure of infants born prematurely with very low birth weight (VLBW). Essential elements of RDS management include ventilatory support and endotracheal administration of a surfactant. To assess the effect of volume-targeted compared to pressure-controlled mechanical ventilation (MV) on circulatory parameters and cerebral oxygenation StO2 in extremely preterm infants. This prospective, cross-over trial enrolled neonates born before 28 weeks of gestation. The patients were ventilated for 3 h in pressure-controlled assist-control (PC-AC) mode, followed by 3 h of volume-guarantee assist-control ventilation (VG-AC). Pulse oximetry (saturation (SpO2) and heart rate (HR)), near-infrared spectroscopy (NIRS), StO2, and electrical cardiometry (EC) were used in monitoring of the patients. Twenty preterm infants with a mean gestational age of 26 weeks were studied. The patients' mean postnatal age was 7.7 days. The SpO2 values and HR were comparable during PC-AC and VG-AC. The mean values of peak inspiratory pressure (PIP), mean airway pressure (MAP) and expiratory tidal volume (VTE) were lower, while the respiratory rate (RR) was higher during PC-VG. There were no significant differences in the mean values of StO2, but based on a comparison of the standard deviations (SD) the StO2 variability was significantly lower during VG-AC. The circulatory parameters were comparable. The StO2 is more stable during VG than PC ventilation. These findings support the use of VG mode in premature infants.
ISSN:1899-5276
DOI:10.17219/acem/128198