Epicardial adipose tissue is associated with increased systolic pulmonary artery pressure in patients with chronic obstructive pulmonary disease

• Published in: The clinical respiratory journal 2021-04, Vol.15 (4), p.406-412
• Main Authors: Kalaycıoğlu, Ezgi, Çetin, Mustafa, Çinier, Göksel, Özyıldız, Ali Gökhan, Durmuş, İsmet, Kırış, Tuncay, Gökdeniz, Tayyar
• Format: Article
• Language: English
• Subjects: Airway management; Chronic obstructive pulmonary disease; epicardial adipose tissue; Pulmonary arteries; pulmonary hypertension; systolic pulmonary arterial pressure
• ISSN: 1752-6981; 1752-699X
• DOI: 10.1111/crj.13316

Objectives Pulmonary hypertension (PHT) is one of the essential predictors of mortality in chronic obstructive pulmonary disease (COPD). It is thought that PHT is due to vasoconstriction secondary to hypoxia caused by airway obstruction in COPD patients; however, loss of capillary bed with emphysema, inflammation, and endothelial dysfunction may also play a role in the development of PHT. Epicardial adipose tissue (EAT) has a role as a metabolically active endocrine organ and secretes various proinflammatory cytokines. We hypothesized that EAT thickness in COPD patients might be associated with the systolic pulmonary arterial pressure (PAPs) level, and we aimed to test it. Methods The present study included 129 consecutive patients with the diagnosis of COPD. All patients underwent transthoracic echocardiographic evaluation. The relationship between PAPs and EAT thickness was evaluated. Results Positive correlations with PAPs were reported with age, EAT, white blood cell (WBC) and GOLD grade score (range 0.197‐0.275, P values 0.026 to 0.002), negative correlations with body‐mass index (BMI), hyperlipidemia, FEV1 (% predicted) and pO2 (range −0.216 to −0.340, P values .014 to