Recurrent angioedema in childhood: hereditary angioedema or histaminergic angioedema?

• Published in: Pediatric dermatology 2021-01, Vol.38 (1), p.143-148
• Main Authors: Ocak, Melike, Nain, Ercan, Şahiner, Ümit Murat, Akin, Mustafa Şenol, Karabiber, Esra, Şekerel, Bülent Enis, Soyer, Özge
• Format: Article
• Language: English
• Subjects: Allergies; Angioedema; Angioedema - diagnosis; Angioedema - epidemiology; Angioedema - etiology; Angioedemas, Hereditary - complications; Angioedemas, Hereditary - diagnosis; Angioedemas, Hereditary - epidemiology; C1‐inhibitor; Child; Child, Preschool; Childhood; Children; Complement C1 Inhibitor Protein; Diagnosis; Edema; Etiology; Female; Genetic disorders; hereditary angioedema; histaminergic angioedema; Humans; Male; Pain; Pediatrics; Pruritus; Skin diseases; Trauma; Urticaria
• ISSN: 0736-8046; 1525-1470
• DOI: 10.1111/pde.14467

Background Recurrent angioedema is a rare entity during childhood. This study aimed to clarify differences between hereditary angioedema (HAE) and histaminergic angioedema (HA) in children. Methods Fifty‐seven children with HAE (male 36.8%, 8.9 years [5.4‐12.5]) and 42 children with recurrent HA (male 42.9%, 11.5 years [8.1‐16.8]) were analyzed. Results The median age at symptom onset (6 [3‐10]; 7.8 [4.5‐13] years), frequency of angioedema episodes within last year (3 [2‐5]; 5 [2‐10]), and duration of symptoms (48 [24‐48]; 24 [12‐48] hours) were similar in the HAE and HA group, respectively. Recurrent urticaria was observed in 7.3% (n = 3) of patients in the HAE group and in 45.2% (n = 19) of the HA group (P