Salivary and serum oxidative stress biomarkers and advanced glycation end products in periodontitis patients with or without diabetes: A cross‐sectional study

• Published in: Journal of periodontology (1970) 2021-09, Vol.92 (9), p.1274-1285
• Main Authors: Altıngöz, Sema Merve, Kurgan, Şivge, Önder, Canan, Serdar, Muhittin A., Ünlütürk, Uğur, Uyanık, Metin, Başkal, Nilgün, Tatakis, Dimitris N., Günhan, Meral
• Format: Article
• Language: English
• Subjects: 4‐hydroxy‐2‐nonenal; 8‐hydroxy‐2‐deoxyguanosine; Dentistry; diabetes mellitus; oxidative stress; periodontitis; type 2
• ISSN: 0022-3492; 1943-3670
• DOI: 10.1002/JPER.20-0406

Background Non‐invasive methods for periodontitis diagnosis would be a clinically important tool. This cross‐sectional study aimed to investigate the association between oxidative stress, glycation, and inflammation markers and periodontal clinical parameters in periodontitis and periodontally healthy patients with type 2 diabetes and corresponding systemically healthy controls. Methods Sixty‐seven periodontally healthy (DM‐H, n = 32) and periodontitis (DM‐P, n = 35) patients with type 2 diabetes, and 54 systemically healthy periodontitis (H‐P, n = 26) and periodontally healthy (H‐H, n = 28) controls were included. Clinical periodontal parameters, body mass index, fasting glucose, hemoglobin A1c (HbA1c), along with saliva and serum 8‐hydroxy‐2′‐deoxyguanosine (8‐OHdG), malondialdehyde (MDA), 4‐hydroxy‐2‐nonenal (4‐HNE), advanced glycation end products (AGE), AGE receptor (RAGE) and high sensitivity C‐reactive protein (hsCRP) levels were recorded and analyzed. Results Salivary 8‐OHdG levels were significantly higher in periodontitis compared to periodontally healthy patients, regardless of systemic status (P