Effect of Traditional Chinese Medicine on Musculoskeletal Symptoms in Breast Cancer: A Systematic Review and Meta-Analysis

Traditional Chinese Medicine (TCM) has been widely used as a complementary medical treatment for arthralgia and other types of pain. The available literature on the effectiveness of TCM on breast cancer patients with musculoskeletal symptoms reports controversial results. The objective of this revie...

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Bibliographic Details
Published in:Journal of pain and symptom management 2021-07, Vol.62 (1), p.159-173
Main Authors: Poo, Chin Long, Dewadas, Hemaniswarri Dewi, Ng, Foong Leng, Foo, Chai Nien, Lim, Yang Mooi
Format: Article
Language:English
Subjects:
aromatase inhibitor-associated musculoskeletal symptoms (AIMSS)
Aromatase Inhibitors - therapeutic use
Bone mineral density
Breast cancer
Breast Neoplasms - drug therapy
Chinese medicine
Clinical trials
Critical incidents
Drugs, Chinese Herbal
Female
Humans
Infrastructure
Literature reviews
Medical journals
Medical treatment
Medicine, Chinese Traditional
Meta-analysis
Minerals
Pain
Quality of Life
Symptoms
Systematic review
Traditional Chinese medicine
Traditional Chinese Medicine (TCM)
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Summary:Traditional Chinese Medicine (TCM) has been widely used as a complementary medical treatment for arthralgia and other types of pain. The available literature on the effectiveness of TCM on breast cancer patients with musculoskeletal symptoms reports controversial results. The objective of this review is to assess the effectiveness of TCM as a treatment option for musculoskeletal symptoms in patients with breast cancer who were treated with aromatase inhibitors (AIs). A comprehensive literature search was conducted using PubMed, the Cochrane Library, SAGE journals, Scopus, EMBASE, Web of Science, Medline, Cumulated Index to Nursing and Allied Health Literature (CINAHL), Chinese Biomedical Literature Database (CBM), Chinese National Knowledge Infrastructure (CNKI), Chinese Scientific Journal Database (VIP), Wanfang, and Chinese Medical Journal Database (CMJ) from May 2020 to November 2020. The literature review included randomized controlled trials (RCTs) of TCM for AI-related musculoskeletal symptoms. Four RCTs incorporating TCM were assessed by meta-analysis and reported favorable effects in reducing worst pain score (n = 284, mean difference [MD]: 2.31; 95% CI, 1.74 to 2.88; P 
ISSN:0885-3924
1873-6513
DOI:10.1016/j.jpainsymman.2020.11.024