Successful Endovascular Treatment for Very-Late-Onset and Acute Progressive Multiple Transplant Renal Segmental Artery Stenoses: A Case Report

• Published in: Transplantation proceedings 2021-05, Vol.53 (4), p.1262-1267
• Main Authors: Shoji, Keisuke, Zen, Kan, Shiotsu, Yayoi, Nakamura, Tsukasa, Yanishi, Kenji, Ushigome, Hidetaka, Kusaba, Tetsuro, Tamagaki, Keiichi, Matoba, Satoaki
• Format: Article
• Language: English
• ISSN: 0041-1345; 1873-2623
• DOI: 10.1016/j.transproceed.2020.09.022

To report the endovascular treatment for acute progressive and very-late-onset multiple segmental small-artery stenoses in transplanted kidney parenchyma presenting with rapidly deteriorating renal function and refractory hypertension in a 65-year-old man. Nineteen years ago, the patient received a living renal transplant via end-to-end anastomosis of the right internal iliac artery for kidney failure caused by chronic glomerulonephritis. His transplant renal function (creatinine: 0.9 mg/dL) and blood pressure were stable for 18 years. Then rapid worsening of renal function (creatinine: 2.5 mg/dL) and refractory hypertension occurred. Magnetic resonance angiography and renal angiography showed multiple small segmental artery stenoses in the transplanted kidney. At the 1-month follow-up consultation, total occlusion of 2 branches traversing the inferior pole of the kidney was observed, revealing acute progression of artery stenosis. Balloon angioplasty was successfully performed on those branches; renal function improved (creatinine: 1.3 mg/dL), and blood pressure was sufficiently controlled. This is a rare case that revealed very-late-onset multiple segmental renal artery stenoses with acute progression in the transplant kidney. Even multiple small segmental artery stenoses can reduce transplant renal function in the chronic phase and progress rapidly. Early percutaneous transluminal angioplasty may thus be feasible and important for preventing graft loss. •A case of late-onset transplanted renal segmental artery stenosis was encountered.•Multiple renal artery stenoses exacerbated problems with renal function and blood pressure control.•Various imaging findings showed severe stenosis and ischemia in transplanted kidney.•PTA for even small segmental artery stenosis was successfully performed.•Significant recovery and sufficient durability were observed.