HCC risk post-SVR with DAAs in East Asians: findings from the REAL-C cohort

Background Despite HCV cure, patients remain at risk for HCC, but risk factor data for HCC following SVR are limited for Asian patients. Methods To address this gap, we analyzed 5814 patients (5646 SVR, 168 non-SVR) from the Real-World Evidence from the Asia Liver Consortium for HCV (REAL-C) who did...

Full description

Saved in:
Bibliographic Details
Published in:Hepatology international 2020-12, Vol.14 (6), p.1023-1033
Main Authors: Tanaka, Yasuhito, Ogawa, Eiichi, Huang, Chung-Feng, Toyoda, Hidenori, Jun, Dae Won, Tseng, Cheng-Hao, Hsu, Yao-Chun, Enomoto, Masaru, Takahashi, Hirokazu, Furusyo, Norihiro, Yeh, Ming-Lun, Iio, Etsuko, Yasuda, Satoshi, Lam, Carla Pui-Mei, Lee, Dong Hyun, Haga, Hiroaki, Yoon, Eileen L., Ahn, Sang Bong, Wong, Grace, Nakamuta, Makoto, Nomura, Hideyuki, Tsai, Pei-Chien, Jung, Jang Han, Song, Do Seon, Dang, Hansen, Maeda, Mayumi, Henry, Linda, Cheung, Ramsey, Yuen, Man-Fung, Ueno, Yoshiyuki, Eguchi, Yuichiro, Tamori, Akihiro, Yu, Ming-Lung, Hayashi, Jun, Nguyen, Mindie H.
Format: Article
Language:English
Subjects:
Albumins
Asian people
Bilirubin
Cirrhosis
Colorectal Surgery
Consortia
Hepatology
Liver cancer
Liver cirrhosis
Medicine
Medicine & Public Health
Original Article
Risk analysis
Risk factors
Subgroups
Surgery
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Despite HCV cure, patients remain at risk for HCC, but risk factor data for HCC following SVR are limited for Asian patients. Methods To address this gap, we analyzed 5814 patients (5646 SVR, 168 non-SVR) from the Real-World Evidence from the Asia Liver Consortium for HCV (REAL-C) who did not have HCC or a history of HCC at baseline (pre-DAA treatment) and did not develop HCC within 6 months of baseline. To assess the effect of SVR on HCC incidence, we used 1:4 propensity score matching [(PSM), age, sex, baseline cirrhosis, and baseline AFP] to balance the SVR and non-SVR groups. Results In the PSM cohort (160 non-SVR and 612 SVR), the HCC incidence rate per 100 person years was higher in the non-SVR compared to the SVR group (5.26 vs. 1.94, p  
ISSN:1936-0533
1936-0541
DOI:10.1007/s12072-020-10105-2