Impact of signet ring cells on overall survival in peritoneal disseminated appendix cancer treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy

• Published in: European journal of surgical oncology 2021-01, Vol.47 (1), p.194-198
• Main Authors: Shamavonian, Raphael, Lansom, Joshua D., Karpes, Josh B., Alzahrani, Nayef A., Morris, David L.
• Format: Article
• Language: English
• Subjects: Appendiceal Neoplasms - mortality; Appendiceal Neoplasms - pathology; Appendiceal Neoplasms - therapy; Appendix cancer; Carcinoma, Signet Ring Cell - mortality; Carcinoma, Signet Ring Cell - pathology; Carcinoma, Signet Ring Cell - secondary; Combined Modality Therapy; Cytoreduction Surgical Procedures; Cytoreductive surgery; Female; Humans; Hyperthermic Intraperitoneal Chemotherapy; Male; Middle Aged; Neoplasm Grading; Neoplasm Staging; Overall survival; Peritoneal Neoplasms - mortality; Peritoneal Neoplasms - secondary; Peritoneal Neoplasms - therapy; Retrospective Studies; Signet ring cell; Survival Analysis
• ISSN: 0748-7983; 1532-2157
• DOI: 10.1016/j.ejso.2020.11.134

To determine the effect of signet ring cell (SRC) histopathology in appendix cancer with peritoneal dissemination on overall survival (OS) in patients undergoing cytoreductive surgery (CRS) and heated intraperitoneal chemotherapy (HIPEC). Retrospective cohort study from a prospectively maintained database of patients that underwent CRS/HIPEC for appendix cancer from April 1999 to December 2019. 255 patients were identified. 174 had high-grade disease with no SRC component, 35 with a low count of SRC and 46 with a high count of SRC. Median OS without SRC was 93.8 months vs 58.2 months for low count SRC and 23.7 months for high count SRC (P