Impact of NRG1 HapICE gene variants on digit ratio and dermatoglyphic measures in schizophrenia

•Neurodevelopmental aberration is an important etiopathogenetic model for schizophrenia.•Neuregulin-1 (NRG1) and dermatoglyphic abnormalities underlie neurodevelopmental origins of schizophrenia.•The impact of two NRG1 polymorphisms the digit ratio and dermatoglyphic measures in schizophrenia was ex...

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Published in:Asian journal of psychiatry 2020-12, Vol.54, p.102363-102363, Article 102363
Main Authors: Rajasekaran, Ashwini, Shivakumar, Venkataram, Kalmady, Sunil V., Parlikar, Rujuta, Chhabra, Harleen, Prabhu, Ananya, Subbanna, Manjula, Venugopal, Deepthi, Amaresha, Anekal C., Agarwal, Sri Mahavir, Bose, Anushree, Narayanaswamy, Janardhanan C., Debnath, Monojit, Venkatasubramanian, Ganesan
Format: Article
Language:English
Subjects:
Dermatoglyphics
Digit ratio
Genotype
Humans
Neuregulin-1
Neuregulin-1 - genetics
Polymorphism, Single Nucleotide
Schizophrenia
Schizophrenia - genetics
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Summary:•Neurodevelopmental aberration is an important etiopathogenetic model for schizophrenia.•Neuregulin-1 (NRG1) and dermatoglyphic abnormalities underlie neurodevelopmental origins of schizophrenia.•The impact of two NRG1 polymorphisms the digit ratio and dermatoglyphic measures in schizophrenia was examined•Significant impact of NRG1 polymorphism - SNP8NRG221533 was observed on digit ratio and dermatoglyphic measures in schizophrenia. Multiple lines of evidence have suggested a potential role of Neuregulin-1 (NRG1) in the neurodevelopmental pathogenesis of schizophrenia. Interaction between genetic risk variants present within NRG1 locus and non-specific gestational putative insults can significantly impair crucial processes of brain development. Such genetic effects can be analyzed through the assessment of digit ratio and dermatoglyphic patterns. We examined the role of two well-replicated polymorphisms of NRG1 (SNP8NRG221533 and SNP8NRG243177) on schizophrenia risk and its probable impact on the digit ratio and dermatoglyphic measures in patients (N = 221) and healthy controls (N = 200). In schizophrenia patients, but not in healthy controls, a significant association between NRG1 SNP8NRG221533 C/C genotype with lower left 2D:4D ratio, as well as with higher FA_TbcRC and DA_TbcRC. The substantial effect of SNP8NRG221533 on both digit ratio and dermatoglyphic measures suggest a potential role for NRG1 gene variants on neurodevelopmental pathogenesis of schizophrenia.
ISSN:1876-2018
1876-2026
DOI:10.1016/j.ajp.2020.102363