Pchaeglobolactone A, Spiropchaeglobosin A, and Pchaeglobosals A and B: Four Rearranged Cytochalasans from Chaetomium globosum P2-2‑2

Four novel rearranged cytochalasans (1–4) were isolated from an endophytic fungus Chaetomium globosum P2-2-2. Pchaeglobolactone A (1) possessed an unprecedented 13-aza-21-oxa-tetracyclo-[10.6.1.217,19.015,19]­henicosane core. Spiropchaeglobosin A (2) was the first example of cytochalasans featuring...

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Bibliographic Details
Published in:Organic letters 2020-12, Vol.22 (24), p.9665-9669
Main Authors: Peng, Xiao-Gang, Liu, Junjun, Gao, Ying, Cheng, Fang, Chang, Jin-Ling, Chen, Juan, Duan, Fang-Fang, Ruan, Han-Li
Format: Article
Language:English
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Summary:Four novel rearranged cytochalasans (1–4) were isolated from an endophytic fungus Chaetomium globosum P2-2-2. Pchaeglobolactone A (1) possessed an unprecedented 13-aza-21-oxa-tetracyclo-[10.6.1.217,19.015,19]­henicosane core. Spiropchaeglobosin A (2) was the first example of cytochalasans featuring a novel spiro[5.10]­hexadecane unit. Pchaeglobosals A (3) and B (4) featured a unique 5/5/13 fused tricyclic ring system. Compounds 1–4 were tested for their antiproliferative, apoptosis, cell cycle arrest, and TRAIL-resistance-overcoming activities on cancer cell lines.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.0c03623