18F-labelled BODIPY dye as a dual imaging agent: Radiofluorination and applications in PET and optical imaging

Dual Positron emission tomography (PET)/optical imaging techniques have captured scientific interest for clinical applications due to their potential as an effective tool for visualizing in vivo information such as disease processes. 4,4′-Difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) dye has been...

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Bibliographic Details
Published in:Nuclear medicine and biology 2021-02, Vol.93, p.22-36
Main Authors: Kwon, Young-Do, Byun, Youngjoo, Kim, Hee-Kwon
Format: Article
Language:English
Subjects:
BODIPY dyes
Dyes
Fluorescent
Fluorine isotopes
Imaging techniques
In vivo methods and tests
Information processing
Medical imaging
Molecular imaging
PET
Photochemicals
Positron emission
Positron emission tomography
Radiofluorination
Substitution reactions
Tomography
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Summary:Dual Positron emission tomography (PET)/optical imaging techniques have captured scientific interest for clinical applications due to their potential as an effective tool for visualizing in vivo information such as disease processes. 4,4′-Difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) dye has been considered an ideal platform strategy to achieve dual PET/optical imaging due to its photochemical nature and chemical structure. Various radiofluorination methods to prepare [18F]BODIPY dye have been developed and established, ranging from nucleophilic substitution reactions to isotope exchange reactions. In addition, 18F-labelled BODIPY dyes for biologically important targets have been used for in vivo and ex vivo studies. These studies proved the practicality of [18F]BODIPY dyes as a hybrid PET/optical imaging probe. In this review, recent advances in the synthesis and biological evaluation of 18F-labelled BODIPY dyes are described. [Display omitted]
ISSN:0969-8051
1872-9614
1872-9614
DOI:10.1016/j.nucmedbio.2020.11.004