18F-labelled BODIPY dye as a dual imaging agent: Radiofluorination and applications in PET and optical imaging

Dual Positron emission tomography (PET)/optical imaging techniques have captured scientific interest for clinical applications due to their potential as an effective tool for visualizing in vivo information such as disease processes. 4,4′-Difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) dye has been...

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Published in:Nuclear medicine and biology 2021-02, Vol.93, p.22-36
Main Authors: Kwon, Young-Do, Byun, Youngjoo, Kim, Hee-Kwon
Format: Article
Language:English
Subjects:
BODIPY dyes
Dyes
Fluorescent
Fluorine isotopes
Imaging techniques
In vivo methods and tests
Information processing
Medical imaging
Molecular imaging
PET
Photochemicals
Positron emission
Positron emission tomography
Radiofluorination
Substitution reactions
Tomography
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container_title Nuclear medicine and biology
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creator Kwon, Young-Do
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description Dual Positron emission tomography (PET)/optical imaging techniques have captured scientific interest for clinical applications due to their potential as an effective tool for visualizing in vivo information such as disease processes. 4,4′-Difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) dye has been considered an ideal platform strategy to achieve dual PET/optical imaging due to its photochemical nature and chemical structure. Various radiofluorination methods to prepare [18F]BODIPY dye have been developed and established, ranging from nucleophilic substitution reactions to isotope exchange reactions. In addition, 18F-labelled BODIPY dyes for biologically important targets have been used for in vivo and ex vivo studies. These studies proved the practicality of [18F]BODIPY dyes as a hybrid PET/optical imaging probe. In this review, recent advances in the synthesis and biological evaluation of 18F-labelled BODIPY dyes are described. [Display omitted]
doi_str_mv 10.1016/j.nucmedbio.2020.11.004
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subjects BODIPY dyes
Dyes
Fluorescent
Fluorine isotopes
Imaging techniques
In vivo methods and tests
Information processing
Medical imaging
Molecular imaging
PET
Photochemicals
Positron emission
Positron emission tomography
Radiofluorination
Substitution reactions
Tomography
title 18F-labelled BODIPY dye as a dual imaging agent: Radiofluorination and applications in PET and optical imaging
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