Maternal obesity is associated with a sex-specific epigenetic programming in human neonatal monocytes

To determine changes in global DNA methylation in monocytes from neonates of women with obesity, as markers of an immune programming resulting from maternal obesity. Cord blood monocytes were obtained from neonates born to women with obesity and normal weight, genome-wide differentially methylated C...

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Bibliographic Details
Published in:Epigenomics 2020-11, Vol.12 (22), p.1999-2018
Main Authors: Vega-Tapia, Fabián, Artigas, Rocío, Hernández, Cherie, Uauy, Ricardo, Casanello, Paola, Krause, Bernardo J, Castro-Rodriguez, Jose A
Format: Article
Language:English
Subjects:
DNA methylation
fetal programming
maternal obesity
monocytes
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Summary:To determine changes in global DNA methylation in monocytes from neonates of women with obesity, as markers of an immune programming resulting from maternal obesity. Cord blood monocytes were obtained from neonates born to women with obesity and normal weight, genome-wide differentially methylated CpGs were determined using an Infinium MethylationEPIC-BeadChip (850K). No clustering of samples according to maternal BMI was observed, but sex-specific analysis revealed 71,728 differentially methylated CpGs in female neonates from women with obesity (p 
ISSN:1750-1911
1750-192X
DOI:10.2217/epi-2020-0098