A case of monofocal motor neuropathy with GM1 and GD1b antibodies improved with intravenous immunoglobulin

Multifocal motor neuropathy is a purely motor neuropathy with a probably dysimmune pathogenesis, supported by the presence of anti-GM1 IgM antibodies in about half of the cases. Single nerve involvement allows for diagnosis of possible multifocal motor neuropathy. We present the case of a middle age...

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Bibliographic Details
Published in:Journal of neuroimmunology 2021-01, Vol.350, p.577452-577452, Article 577452
Main Authors: Mantero, Vittorio, Basilico, Paola, Borelli, Paolo, Cappello, Antonio, Salmaggi, Andrea, Rigamonti, Andrea
Format: Article
Language:English
Subjects:
Anti-GD1b antibodies
Anti-GM1 antibodies
Intravenous immunoglobulin
Monofocal motor neuropathy
Multifocal motor neuropathy
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Summary:Multifocal motor neuropathy is a purely motor neuropathy with a probably dysimmune pathogenesis, supported by the presence of anti-GM1 IgM antibodies in about half of the cases. Single nerve involvement allows for diagnosis of possible multifocal motor neuropathy. We present the case of a middle age man presenting with progressive weakness and hypotrophy in the left leg and difficulty in walking, in which we have diagnosed a dysimmune mononeuropathy. Treatment with IVIg was performed with substantial improvement. Although only one nerve is involved, early diagnosis of dysimmune mononeuropathy is important to start IVIg treatment that is often decisive. [Display omitted]
ISSN:0165-5728
1872-8421
DOI:10.1016/j.jneuroim.2020.577452