Renal function as a predictor of outcomes in patients with hypertrophic cardiomyopathy: A cohort study of a hospitalized population

•Renal dysfunction was a common comorbidity in patients with HCM.•Renal function was an independent predictor of outcomes in patients with HCM.•Age played an interactive role in the association between renal function and death. The relationship between renal function and outcomes among patients with...

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Published in:Clinica chimica acta 2021-01, Vol.512, p.92-99
Main Authors: Huang, Fang-Yang, Zhang, Jia-Liang, Huang, Bao-Tao, Peng, Yong, Chen, Shi-Jian, Chen, Mao
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Language:English
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Hypertrophic cardiomyopathy
Prognosis
Renal function
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description •Renal dysfunction was a common comorbidity in patients with HCM.•Renal function was an independent predictor of outcomes in patients with HCM.•Age played an interactive role in the association between renal function and death. The relationship between renal function and outcomes among patients with hypertrophic cardiomyopathy (HCM) remains undefined. We sought to investigate the prevalence of renal dysfunction and its prognostic value in HCM patients. A total of 581 patients with HCM were consecutively recruited. The chronic kidney disease epidemiology equation was used to estimate the glomerular filtration rate (eGFR). Patients were divided into 2 eGFR categories: ≥60 or
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The relationship between renal function and outcomes among patients with hypertrophic cardiomyopathy (HCM) remains undefined. We sought to investigate the prevalence of renal dysfunction and its prognostic value in HCM patients. A total of 581 patients with HCM were consecutively recruited. The chronic kidney disease epidemiology equation was used to estimate the glomerular filtration rate (eGFR). Patients were divided into 2 eGFR categories: ≥60 or &lt;60 ml/min/1.73 m2. The predictive value of renal function was assessed using Cox regression. The proportions of eGFR 60–90 ml/min/1.73 m2 and &lt;60 ml/min/1.73 m2 were 41.8% and 15.3%, respectively. Estimated GFR independently predicted the risk of all-cause mortality [HR 0.98, 95% confidence interval (CI) 0.96–0.99, P &lt; 0.001]. Compared to those with eGFR ≥ 60 ml/min/1.73 m2, patients with eGFR &lt; 60 ml/min/1.73 m2 were independently associated with all-cause mortality (HR, 3.42 95% CI 1.86–6.28), cardiovascular mortality (HR 2.98, 95% CI 1.36–6.50) and combined adverse outcomes (HR 1.60, 95% CI 1.02–2.49). HRs for all-cause mortality with renal dysfunction were attenuated in patients with older ages (P for interaction = 0.034). Renal dysfunction is a common comorbidity in HCM. Renal function is an independent predictor of outcomes in patients with HCM. 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Compared to those with eGFR ≥ 60 ml/min/1.73 m2, patients with eGFR &lt; 60 ml/min/1.73 m2 were independently associated with all-cause mortality (HR, 3.42 95% CI 1.86–6.28), cardiovascular mortality (HR 2.98, 95% CI 1.36–6.50) and combined adverse outcomes (HR 1.60, 95% CI 1.02–2.49). HRs for all-cause mortality with renal dysfunction were attenuated in patients with older ages (P for interaction = 0.034). Renal dysfunction is a common comorbidity in HCM. Renal function is an independent predictor of outcomes in patients with HCM. 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subjects Hypertrophic cardiomyopathy
Prognosis
Renal function
title Renal function as a predictor of outcomes in patients with hypertrophic cardiomyopathy: A cohort study of a hospitalized population
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