Impact of Age on Gender Difference in Long-term Outcome of Patients With Acute Myocardial Infarction (from J-MINUET)

• Published in: The American journal of cardiology 2021-03, Vol.142, p.5-13
• Main Authors: Kimura, Toshio, Akahori, Hirokuni, Asakura, Masanori, Nakao, Koichi, Ozaki, Yukio, Kimura, Kazuo, Ako, Junya, Noguchi, Teruo, Suwa, Satoru, Fujimoto, Kazuteru, Nakama, Yasuharu, Morita, Takashi, Shimizu, Wataru, Saito, Yoshihiko, Hirohata, Atsushi, Morita, Yasuhiro, Inoue, Teruo, Okamura, Atsunori, Mano, Toshiaki, Wake, Minoru, Tanabe, Kengo, Shibata, Yoshisato, Owa, Mafumi, Tsujita, Kenichi, Funayama, Hiroshi, Kokubu, Nobuaki, Kozuma, Ken, Uemura, Shiro, Toubara, Tetsuya, Saku, Keijiro, Oshima, Shigeru, Nishimura, Kunihiro, Miyamoto, Yoshihiro, Ogawa, Hisao, Ishihara, Masaharu
• Format: Article
• Language: English
• Subjects: Adrenergic beta-Antagonists - therapeutic use; Age; Age Factors; Aged; Aged, 80 and over; Angina; Angina, Unstable - epidemiology; Angina, Unstable - surgery; Atrial Fibrillation - epidemiology; Cerebral infarction; Congestive heart failure; Coronary Angiography; Female; Gender; Gender differences; Guideline Adherence - statistics & numerical data; Heart attacks; Heart Failure - epidemiology; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use; Ischemia; Japan - epidemiology; Longitudinal Studies; Male; Middle Aged; Mortality; Myocardial infarction; Myocardial Infarction - epidemiology; Myocardial Infarction - therapy; Myocardial Revascularization - statistics & numerical data; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors - therapeutic use; Practice Guidelines as Topic; Prognosis; Recurrence; Registries; Renal Insufficiency, Chronic - epidemiology; Sex Factors; Stroke - epidemiology; Time-to-Treatment - statistics & numerical data; Women
• ISSN: 0002-9149; 1879-1913
• DOI: 10.1016/j.amjcard.2020.11.042

Although gender difference in long-term outcomes after acute myocardial infarction have been shown previously, impact of age on gender difference is still controversial. This study focused on the association between age and gender difference in long-term outcome. We analyzed data from 3,283 consecutive patients who were included in a prospective, nationwide, multicenter registry (Japan Registry of Acute Myocardial Infarction Diagnosed by Universal Definition) from 2012 to 2014. The primary end point was the major adverse cardiovascular event (MACE), which was defined as a composite of death, myocardial infarction, stroke, heart failure, and revascularization for unstable angina during 3 years. Patients were divided into 4 strata according to age: those with age