Comparisons of early and late presentation to hospital in COVID‐19 patients

Currently, there are little data on the relationship between the timing of symptom onset at presentation to hospital and disease outcome. [...]we aimed to identify the differences between ‘early presenters’ (patients presenting to hospital

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Published in:Respirology 2021-02, Vol.26 (2), p.204-205
Main Authors: Williams, Sarah, Sheard, Natasha, Stuart, Beth, Phan, Hang T.T., Borca, Florina, Wilkinson, Tom M.A., Burke, Hannah, Freeman, Anna
Format: Article
Language:English
Subjects:
COVID-19
COVID-19 - complications
COVID-19 - diagnostic imaging
Hospitals
Humans
Patient Acceptance of Health Care
Prognosis
Retrospective Studies
SARS-CoV-2
Severity of Illness Index
Time Factors
Time-to-Treatment
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cited_by cdi_FETCH-LOGICAL-c4215-4552c37cef48d586277d0a6393b431cac9f15b8b6dd3bb369e986d4059dda9313
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container_end_page 205
container_issue 2
container_start_page 204
container_title Respirology
container_volume 26
creator Williams, Sarah
Sheard, Natasha
Stuart, Beth
Phan, Hang T.T.
Borca, Florina
Wilkinson, Tom M.A.
Burke, Hannah
Freeman, Anna
description Currently, there are little data on the relationship between the timing of symptom onset at presentation to hospital and disease outcome. [...]we aimed to identify the differences between ‘early presenters’ (patients presenting to hospital
doi_str_mv 10.1111/resp.13985
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[...]we aimed to identify the differences between ‘early presenters’ (patients presenting to hospital <7 days from symptom onset) and ‘late presenters’ (≥7 days from symptom onset). Symptoms at the time of presentation to hospital in ‘early’ and ‘late’ presenters Symptoms Early presenters (n = 388) Late presenters (n = 238) P‐value for difference Fever 225/352 (63.9%) 152/182 (83.5%) <0.001 Cough 235/339 (69.3%) 174/190 (91.6%) <0.001 Shortness of breath 211/328 (64.3%) 165/190 (86.8%) <0.001 Myalgia 21/49 (42.9%) 45/57 (79.0%) <0.001 Arthralgia 10/26 (38.5%) 9/12 (75.0%) 0.04 Fatigue/malaise 143/182 (78.6%) 127/130 (97.7%) <0.001 Headache 26/80 (32.5%) 36/59 (61.0%) 0.001 Confusion 125/265 (47.2%) 41/119 (34.5%) 0.02 Diarrhoea 53/162 (32.7%) 49/107 (45.8%) 0.03 Cold symptoms 36/67 (53.7%) 35/51 (68.6%) 0.1 Wheezing 37/165 (22.4%) 13/64 (20.3%) 0.7 Chest pain 49/207 (23.7%) 32/128 (25.0%) 0.8 Abdominal pain 32/173 (18.5%) 18/97 (18.6%) 0.9 Vomiting 39/144 (27.1%) 32/96 (33.3%) 0.3 Chi‐square statistical test was used to determine significance. The precise mechanisms of hyperinflammatory responses in COVID‐19 are unknown but a theorized ‘inflection point’ between early infection and the respiratory phase with hyperinflammatory response occurs 5–7 days post‐symptom onset,3 which represents our ‘early presenter’ cohort. 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Symptoms at the time of presentation to hospital in ‘early’ and ‘late’ presenters Symptoms Early presenters (n = 388) Late presenters (n = 238) P‐value for difference Fever 225/352 (63.9%) 152/182 (83.5%) <0.001 Cough 235/339 (69.3%) 174/190 (91.6%) <0.001 Shortness of breath 211/328 (64.3%) 165/190 (86.8%) <0.001 Myalgia 21/49 (42.9%) 45/57 (79.0%) <0.001 Arthralgia 10/26 (38.5%) 9/12 (75.0%) 0.04 Fatigue/malaise 143/182 (78.6%) 127/130 (97.7%) <0.001 Headache 26/80 (32.5%) 36/59 (61.0%) 0.001 Confusion 125/265 (47.2%) 41/119 (34.5%) 0.02 Diarrhoea 53/162 (32.7%) 49/107 (45.8%) 0.03 Cold symptoms 36/67 (53.7%) 35/51 (68.6%) 0.1 Wheezing 37/165 (22.4%) 13/64 (20.3%) 0.7 Chest pain 49/207 (23.7%) 32/128 (25.0%) 0.8 Abdominal pain 32/173 (18.5%) 18/97 (18.6%) 0.9 Vomiting 39/144 (27.1%) 32/96 (33.3%) 0.3 Chi‐square statistical test was used to determine significance. 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subjects COVID-19
COVID-19 - complications
COVID-19 - diagnostic imaging
Hospitals
Humans
Patient Acceptance of Health Care
Prognosis
Retrospective Studies
SARS-CoV-2
Severity of Illness Index
Time Factors
Time-to-Treatment
title Comparisons of early and late presentation to hospital in COVID‐19 patients
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